In Lyon, phage therapy against antibiotic resistance at the Croix-Rousse bone and joint infection centre

Feature on the Reference Center for Complex Osteoarticular Infections (CrioaC) at Croix-Rousse Hospital in Lyon, where Professor Tristan Ferry's team treats patients at a therapeutic impasse with phages, a treatment the service has pioneered in France. Because phage therapy is not yet authorized in France, it is given in a tightly controlled way: under a compassionate-access authorization (AAC) validated by the ANSM, free of charge outside that route, or within a phase II clinical trial run with Phaxiam. Phages are generally injected as a cocktail of two or three, often under ultrasound; the article first appeared in ActuSoins magazine no. 53 (June 2024).