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Paul Kim (Locus Biosciences, Inc.) and colleagues published a paper on the results of the first phase of their Phase 2 ELIMINATE clinical trial, where they used a CRISPR-Cas3-enhanced phage cocktail to treat uncomplicated urinary tract infe

Tea Glonti (Queen Astrid Military Hospital) and colleagues published a new paper on designing therapeutic phage cocktails based on naturally occurring phage groupings. They transferred naturally occurring phage groups directly from their so

Joshua Jones (UK Phage Therapy, University of Edinburgh) and colleagues have provided guidelines for assessing patient suitability for unlicensed phage therapy in the UK, showing clinical and microbiological considerations for local clinica

A hydrogel loaded with a phage cocktail and vancomycin gave a 99.72% reduction in MRSA biofilm in vitro and maintained activity for eight days. In vivo, the co-delivery hydrogel with systemic antibiotic reduced bacterial load by 0.99 log10

In episode 2 of the Podovirus podcast, 'Getting Phage Research Funded', Jessica Sacher interviews Dr. Joe Campbell, who spent the past decade+ as a program officer at NIAID, the US gov's main infectious disease funding body. Dr. Campbell r

Daria Van Tyne (University of Pittsburgh) received a $70K grant to optimize phage therapy for Burkholderia spp. infections, showing potential advancements in treating cystic fibrosis patients. Also, Daria has just been promoted to Associate

Dr. Siân Owen was interviewed the You Make Me Sick podcast about her work using experimental evolution and computational approaches to study AMR bacteria and phages during her postdoc at the Baym Lab at Harvard Medical School. She announced

Katrine Whiteson (University of California, Irvine) has been awarded a Pilot Program grant for phage therapy research by the Susan Samueli Integrative Health Institute to develop and refine phage therapy protocols for treating antibiotic-re

Yuval Mulla (University of Cologne) and colleagues quantified phage amplification rates using a mathematical model called PHORCE, showing that amplification rates of E. coli phages vary widely and that phage-antibiotic interactions depend p

Stephen Tang (Columbia University) and colleagues described de novo gene synthesis by an antiviral reverse transcriptase, showing a novel approach to gene synthesis.

Adrián Cortés-Martín (University College Cork) and colleagues published a new paper on isolation and characterization of Septuagintavirus, showing a novel clade of Escherichia coli phages within the subfamily Vequintavirinae.

Célia Souque (Harvard Medical School) and colleagues published a new paper reviewing evolutionary mechanisms driving antibiotic resistance at different scales.

In episode 2 of the Podovirus podcast, 'Getting Phage Research Funded', Jessica Sacher interviews Dr. Joe Campbell, who spent the past decade+ as a program officer at NIAID, the US gov's main infectious disease funding body. Dr. Campbell r

This review describes the computational tools used by SEA-PHAGES and PHIRE to analyze phage genomes, extract prophages, group related genes into phamilies, and visualize genome mosaicism. The tools are freely available to the phage communit

“We created a MASH database for rapid searching of closely related phages, to then be compared with BLASTn to compute intergenomic similarity between bacteriophages.” The authors report that taxmyPHAGE is available as a conda repository and

Dr. Katharina Höfer (Philipps University Marburg) has been awarded a LOEWE top professorship — 2.8 million euros over a period of five years to support her research into the role of RNA modifications in biology and new mechanisms of gene re

Ellie Jameson (Bangor University), environmental virologist and scientific illustrator, has published her phage art collection (drawings, cartoons, etc!) on her new website. Check out her work (& reach out to commission her to illustrate yo

The Phage Hunters Training and Research Program in Nairobi has been hosting a ‘Antimicrobial Resistance (AMR) and Phage Therapy series’ on LinkedIn Live — recordings are available! Recently they had a panel on AMR and phage therapy, and ano

Ashlan Kunz Coyne (Wayne State University, Detroit, USA) and colleagues published a new paper on evaluating phage-antibiotic combinations against ESKAPE pathogens, showing synergistic and antagonistic interactions.

Cody Martin (University of Wisconsin-Madison) and colleagues published a new preprint on Protein Set Transformer: A protein-based genome language model to power high diversity viromics.