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  • Phage prohead proteases activate CBASS antiphage immunity (Science)

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  1. UpdatesSep 13, 2024

    Nicolas Kieffer (Universidad Complutense de Madrid) and colleagues published a new preprint on identification of phage defens

    Nicolas Kieffer (Universidad Complutense de Madrid) and colleagues published a new preprint on identification of phage defense systems encoded by mobile integrons, showing that integrons can encode phage defense systems, including Lamassu,

    UpdatesPhage defenseIntegronsResearch paper
  2. JobsAug 29, 2024

    The Société Française de Bioinformatique, Lyon, France is hiring a Master's level bioinformatician to study the phageomes and

    The Société Française de Bioinformatique, Lyon, France is hiring a Master's level bioinformatician to study the phageomes and counter-defensomes of microbial communities.

    JobsBioinformaticsPhage defense
  3. UpdatesJul 26, 2024

    Florian Tesson (Institut Pasteur) and colleagues published a new paper on the DefenseFinder webservice/wiki/database for anti

    Florian Tesson (Institut Pasteur) and colleagues published a new paper on the DefenseFinder webservice/wiki/database for antiphage defense mechanisms, showing an updated resource with 152 identified systems.

    UpdatesPhage DefenseBioinformaticsResource Hub
  4. UpdatesMay 10, 2024

    From David Bikard via Twitter: Hello phage phriends. Do you have examples of anti-phage defense systems that were shown to to

    From David Bikard via Twitter: Hello phage phriends. Do you have examples of anti-phage defense systems that were shown to tolerate lysogeny but target the phage when it enters its lytic cycle ? (beyond type III CRISPR)

    UpdatesCommunityQuestionTwitterPhage defense
  5. JobsApr 5, 2024

    Pieter-Jan Haas’ group at UMC Utrecht is seeking a postdoc to identify the most relevant defense and counter defense mechanis

    Pieter-Jan Haas’ group at UMC Utrecht is seeking a postdoc to identify the most relevant defense and counter defense mechanisms in clinical strains and phages of the bacterial pathogen P. aeruginosa.

    JobsPostdocPhage defense
  6. UpdatesMar 1, 2024

    Ana Rita Costa (Delft University of Technology) and colleagues published a new paper showing that clinical P. aeruginosa stra

    Ana Rita Costa (Delft University of Technology) and colleagues published a new paper showing that clinical P. aeruginosa strains accumulate phage defense systems (some have at least 19!), that many individual defense systems target specific

    UpdatesPhage defenseResearch paper
  7. UpdatesFeb 24, 2024

    From David Bikard via Twitter: A question to the phage aficionado. Do you have clear examples of anti-phage defense systems t

    From David Bikard via Twitter: A question to the phage aficionado. Do you have clear examples of anti-phage defense systems that block the production or assembly of phage particles without targeting the phage DNA and without resulting in ce

    UpdatesCommunityPhage defenseQuestion
  8. JobsFeb 24, 2024

    The Atkinson lab at Lund University, Sweden are seeking a bioinformatics PhD student to be involved in the Novo Nordisk funde

    The Atkinson lab at Lund University, Sweden are seeking a bioinformatics PhD student to be involved in the Novo Nordisk funded project: ‘Development of phage biocontrol to overcome the antiphage defense system arsenal of phytopathogenic Ral

    JobsBioinformaticsPhD projectPhage defense
  9. JobsFeb 24, 2024

    The Friman lab at the University of Helsinki, Finland is hiring a postdoc to develop phage biocontrol to overcome the antipha

    The Friman lab at the University of Helsinki, Finland is hiring a postdoc to develop phage biocontrol to overcome the antiphage defense system arsenal of phytopathogenic Ralstonia solanacearum bacterium.

    JobsPhage BiocontrolPlant pathogensPhage defense
  10. JobsFeb 24, 2024

    The Fossati lab at the Karolinska Institutet, Sweden is hiring a postdoc in the field of bacterial antiphage systems. The lab

    The Fossati lab at the Karolinska Institutet, Sweden is hiring a postdoc in the field of bacterial antiphage systems. The lab investigates bacterial immune system composition and mechanisms by employing bulk NGS and high-throughput proteomi

    JobsPhage defenseMachine learningPostdoc
  11. UpdatesDec 22, 2023

    Kishen Patel and Kimberley Seed (University of California, Berkeley) published a new preprint on how a sporadic phage defense

    Kishen Patel and Kimberley Seed (University of California, Berkeley) published a new preprint on how a sporadic phage defense in epidemic Vibrio cholerae (mediated by the toxin-antitoxin system DarTG) is countered by a phage-encoded antitox

    UpdatesPhage DefenseToxin-Antitoxin SystemPreprint
  12. UpdatesNov 17, 2023

    Mikhail Skutel and colleagues demonstrate how the T5-like phage BF23 evades host-mediated DNA restriction and methylation.

    Mikhail Skutel and colleagues demonstrate how the T5-like phage BF23 evades host-mediated DNA restriction and methylation.

    UpdatesResearch PaperPhage defense
  13. JobsNov 17, 2023

    Ana Cristina Afonso Oliveira (CEB at University of Minho, Braga, Portugal) is seeking a PhD student to study phages to overco

    Ana Cristina Afonso Oliveira (CEB at University of Minho, Braga, Portugal) is seeking a PhD student to study phages to overcome ETEC's phage defence systems.

    JobsPhD projectPhage defense
  14. UpdatesOct 20, 2023

    Lydia Chambers and colleagues discovered that bacterial antiviral defense pathways encode eukaryotic-like ubiquitination syst

    Lydia Chambers and colleagues discovered that bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems, revealing strong parallels between bacterial and eukaryotic ubiquitination pathways.

    UpdatesResearch paperPhage defense
  15. JobsOct 6, 2023

    The research group of Dr Andrea Fossati at Karolinska Institute, Sweden seeks a postdoc to study phage defense systems in myc

    The research group of Dr Andrea Fossati at Karolinska Institute, Sweden seeks a postdoc to study phage defense systems in mycobacteria.

    JobsPhage defenseMycobacteria Defense SystemsPostdoc
  16. JobsSep 29, 2023

    The Frunzke lab (Forschungszentrum Jülich, Germany) is seeking a PhD student to study bacterial antiviral immunity.

    The Frunzke lab (Forschungszentrum Jülich, Germany) is seeking a PhD student to study bacterial antiviral immunity.

    JobsPhD projectPhage defense
  17. JobsSep 8, 2023

    Washington University is hiring a Research Technician II - Molecular Microbiology to study the molecular arms race between ba

    Washington University is hiring a Research Technician II - Molecular Microbiology to study the molecular arms race between bacteria and these viruses by discovering and characterizing new bacterial phage defense mechanisms.

    JobsMolecular MicrobiologyResearch TechnicianPhage defense
  18. UpdatesJun 23, 2023

    Elliot Macdonald and colleagues at Newcastle University have identified a new anti-phage system called Shield, found in Pseud

    Elliot Macdonald and colleagues at Newcastle University have identified a new anti-phage system called Shield, found in Pseudomonas, made of a core component ShdA and a membrane-bound protein with an RmuC domain, which provides a new mechan

    UpdatesResearch paperPhage defense
  19. JobsJun 2, 2023

    The LeRoux lab at Washington University School of Medicine is seeking a postdoc to investigate phage defense mechanisms in op

    The LeRoux lab at Washington University School of Medicine is seeking a postdoc to investigate phage defense mechanisms in opportunistic pathogens. This study will inform efforts to develop phage therapy against high priority pathogens.

    JobsPhage defensePhage therapyPostdoc
  20. UpdatesJun 2, 2023

    Tanita Wein and colleagues have published a new preprint on caspase recruitment domains (CARDs), which play a crucial role in

    Tanita Wein and colleagues have published a new preprint on caspase recruitment domains (CARDs), which play a crucial role in inflammasome activity and pyroptosis. They found that CARD-like domains are present in phage defense systems, and

    UpdatesPhage defenseCaspase recruitment domains
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