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Zhiying Zhang (Memorial Sloan Kettering Cancer Center) and colleagues published a new paper on a membrane-embedded Kiwa defense supercomplex mechanism, showing KwaA and KwaB form transmembrane complexes that detect phage attachment and bind

Toni Nagy (University of Colorado, Boulder) and colleagues published a new paper on systematic identification of phage immune triggers, showing that screening 400 phage proteins across 72 E. coli strains revealed over 100 phage-host immune

Marina Mahler (University of Otago) and colleagues published a new paper on arabinosyl-hydroxy-cytosine DNA modifications, showing that these modifications enable phages to evade DNA-targeting CRISPR-Cas and restriction systems while remain

Xiang Hou (Jiangsu Academy of Agricultural Sciences, China) and colleagues published a new paper on a repressor, RptR, that controls Type I restriction modification system defence islands. They show that RptR binds TAGCTA repeats to silence

Stephen Tang (Columbia University) and colleagues published a new paper on protein-primed homopolymer synthesis, showing a novel bacterial antiviral defense mechanism involving synthesis of poly-dA DNA triggered by phage infection, driven b

Giuseppina Mariano, Justin Deme (University of Glasgow & National Cancer Institute) and colleagues published a new paper on structural and mechanistic insights into Zorya phage defense systems, showing ZorAB forms an ion-driven motor comple

Tanita Wein (Weizmann Institute of Science) and colleagues published a new paper on bacterial CARD domains in anti-phage defense, showing that CARD domains are essential for protease-mediated activation of bacterial gasdermins that trigger

University of Glasgow is hiring a Research Associate, to study mechanisms and evolutionary dynamics of phage-anti-phage systems, specifically newly discovered anti-phage systems in Pseudomonas aeruginosa.

University of Glasgow is hiring a Research Associate, to study mechanisms and evolutionary dynamics of phage-anti-phage systems, specifically newly discovered anti-phage systems in Pseudomonas aeruginosa.

University of Glasgow is hiring a Research Associate, to study mechanisms and evolutionary dynamics of phage-anti-phage systems, specifically newly discovered anti-phage systems in Pseudomonas aeruginosa.

University of Glasgow is hiring a Research Associate, to study mechanisms and evolutionary dynamics of phage-anti-phage systems, specifically newly discovered anti-phage systems in Pseudomonas aeruginosa.

Owen Tuck (University of California, Berkeley) and colleagues published a new paper on Hachiman antiphage defense complex, showing Hachiman is a nuclease-helicase complex that senses genome integrity and degrades DNA upon detecting damage,

Susu Jiang, Chau Chen (Shenzhen University Medical School) and colleagues published a new paper on how a phage-encoded kinase phosphorylates multiple host defense systems including DndFGH and CRISPR-Cas to enable infection.

Lund University is hiring a Postdoctoral researcher, to study molecular mechanisms of antiphage defense systems using phage microbiology, biochemistry, and structural biology approaches in Vasili Hauryliuk's lab.

Lund University is hiring a Postdoctoral researcher, to study molecular mechanisms of antiphage defense systems using phage microbiology, biochemistry, and structural biology approaches in Vasili Hauryliuk's lab.

Léa Ibarlosa (CNRS-Université de Bordeaux, France) and colleagues published a new paper on amyloid signaling in antiphage defense, showing that amyloid proteins Bab and Agp form a novel E. coli antiphage system activating cell death upon in

Susu Jiang (Shenzhen University Medical School, China) and colleagues published a new paper on phage-encoded kinase evading bacterial defenses, showing the JSS1_004 protein phosphorylates multiple bacterial defense systems to enable phage i

Dong Li (Beijing University of Chemical Technology) and colleagues published a new paper on how phage proteins can sequester signaling molecules from TIR and cGAS-like antiviral defense enzymes. Also check out this explainer thread by coau

Tong Zhang (Massachusetts Institute of Technology) and colleagues discovered a bacterial immunity protein that senses two unrelated phage proteins, showing that CapRelSJ46 in E. coli can directly bind two structurally different phage protei

Dr. Andrea Fossati at the Karolinski Institute is seeking a postdoctoral researcher in phage biology and antimicrobial resistance to work on phage defense systems.