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Cell wall deficiency may limit the efficacy of phage therapy.

Fatima Aysha Hussain (Massachusetts Institute of Technology, Massachusetts) and colleagues published a new paper in Science showing rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages.

Elhanan Tzipilevich (Duke University) and colleagues published a new paper in mBio showing how phage-resistant bacteria reveal a role for potassium in root colonization.

Erin Attrill (University of Exeter, UK) and colleagues published a new paper in PLOS Biology showing individual bacteria in structured environments rely on phenotypic resistance to phage.

Pawel Markwitz (University of Wroclaw, Poland) and colleagues published a new paper in ISME on genome-driven elucidation of phage-host interplay and the impact of phage resistance evolution on bacterial fitness. They systematically assessed

Xiaoqing Wang (Zhejiang University-University of Edinburgh Institute, China) and colleagues published a new preprint on how phage resistance mechanisms increase colistin sensitivity in Acinetobacter baumannii.

Aleksandra Petrovic Fabijan (Westmead Institute for Medical Research) and colleagues published a preprint on L-form switching in pathogenic Escherichia coli. They demonstrated that the osmotically fragile L-form is highly tolerant of oxidat

Dimitrios Skliros (Agricultural University of Athens, Greece) and colleagues published a new paper in Viruses describing how the development of phage resistance in Vibrio alginolyticus depends on a complex metabolic adaptation strategy.

Shayla Hesse (National Cancer Institute, USA) and colleagues published a new paper showing that mutations in genes coding for cell surface structures impair adsorption of phages in multidrug-resistant Klebsiella pneumoniae. They concluded t

Fernando Gordillo Altamirano (Monash University, Australia) and colleagues published a new paper in Nature Microbiology showing that phage-resistant Acinetobacter baumannii are resensitized to antimicrobials. They found that phage-resistant

Vivek Mutalik (Lawrence Berkeley National Lab) and colleagues published their method of high-throughput mapping of the phage resistance landscape in E. coli in PLoS Biology. Sound familiar? We highlighted this paper's corresponding preprint

Fernando Gordillo Altamirano (Monash University, Australia) and colleagues have published a new preprint on Acinetobacter baumannii phage resistance. They found that phage-resistant mutants were sensitive to complement, other phages, and an

A new Infection and Immunity minireview by Mihnea Mangalea and Breck Duerkop (University of Colorado) explores mechanisms and consequences of phage resistance.

Fernando Gordillo Altamirano (Monash University, Australia) and colleagues have published a new preprint on Acinetobacter baumannii phage resistance. They found that phage-resistant mutants were sensitive to complement, other phages, and an

A new Infection and Immunity minireview by Mihnea Mangalea and Breck Duerkop (University of Colorado) explores mechanisms and consequences of phage resistance.

Why do bacteria evolve CRISPR-based phage resistance in natural environments, while in the lab, they seem to more readily evolve receptor-based resistance? Ellinor Alseth (University of Exeter) and colleagues have published a new paper digg

Why do bacteria evolve CRISPR-based phage resistance in natural environments, while in the lab, they seem to more readily evolve receptor-based resistance? Ellinor Alseth (University of Exeter) and colleagues have published a new paper digg

We collectively don’t know much about how phages work in cocktails, or how best to optimize phage therapy when multiple phages are combined. Rosanna Wright (University of York) and colleagues have shown, using P. aeruginosa and pairs of pha

We collectively don’t know much about how phages work in cocktails, or how best to optimize phage therapy when multiple phages are combined. Rosanna Wright (University of York) and colleagues have shown, using P. aeruginosa and pairs of pha

Dr. Tim Blower, Durham, UK Applications are invited for a Postdoctoral Research Associate in BREX phage-resistance systems. BREX methylates the host at specific recognition sequences, but the mechanism of BREX phage protection is not yet u