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Ep 18: Discussion of Phage Therapy for CF Patients - Rebekah Dedrick

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  • Phage prohead proteases activate CBASS antiphage immunity (Science)

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  1. UpdatesJul 19, 2024

    The iVoM webinar series season 3 concluded with great success, attracting over 600 registrations from 11 countries and featur

    The iVoM webinar series season 3 concluded with great success, attracting over 600 registrations from 11 countries and featuring 23 speakers, including 18 early-career researchers, discussing the latest research and advancements in microbia

    UpdatesCommunityWebinar seriesiVoMISVM
  2. UpdatesJul 19, 2024

    The ISVM has released its Viruses of Microbes-themed issue in microLife journal! Led by Prof. Martin Loessner and Prof. Alexa

    The ISVM has released its Viruses of Microbes-themed issue in microLife journal! Led by Prof. Martin Loessner and Prof. Alexander Harms, the issue highlights recent discoveries in bacterial immunity mechanisms and the importance of phages i

    UpdatesCommunityISVMSpecial issueViruses of Microbes
  3. UpdatesJul 19, 2024

    Armata Pharmaceuticals has completed enrollment of its Phase 2 Tailwind study, which will evaluate efficacy of inhaled AP-PA0

    Armata Pharmaceuticals has completed enrollment of its Phase 2 Tailwind study, which will evaluate efficacy of inhaled AP-PA02 in non-CF bronchiectasis patients with chronic pulmonary P. aeruginosa infection. Data anticipated in the second

    UpdatesClinical trialPhage therapy
  4. UpdatesJul 19, 2024

    Proteon Pharmaceuticals, JAFRAL, and PTC Phage Technology Center have established a non-profit organization called PhageEU in

    Proteon Pharmaceuticals, JAFRAL, and PTC Phage Technology Center have established a non-profit organization called PhageEU in Brussels. With newly elected members of EU Parliament and European Commission coming into office, PhageEU sees an

    UpdatesNonprofitPolicyRegulatoryPhage therapy
  5. UpdatesJul 19, 2024

    Jens Hör (Helmholtz Institute for RNA-based Infection Research, Würzburg, Germany) and colleagues at the Weizmann Institute o

    Jens Hör (Helmholtz Institute for RNA-based Infection Research, Würzburg, Germany) and colleagues at the Weizmann Institute of Science have discovered that bacteria conjugate ubiquitin-like proteins to interfere with phage assembly. Here’s

    UpdatesResearch paperPhage assemblyUbiquitin-Like Proteins
  6. UpdatesJul 19, 2024

    Mark Grevsen Martinet (Jena University Hospital/Friedrich-Schiller University, Germany) and colleagues have published a prepr

    Mark Grevsen Martinet (Jena University Hospital/Friedrich-Schiller University, Germany) and colleagues have published a preprint on how temperate Pf-like phages induced in P. aeruginosa biofilms can modulate phage and antibiotic resistance,

    UpdatesPreprintPf phageTemperate phagesCystic fibrosis
  7. UpdatesJul 19, 2024

    Always great to find phage researchers in countries we haven’t had representation from before! Tasnime Abdou Ahmad (American

    Always great to find phage researchers in countries we haven’t had representation from before! Tasnime Abdou Ahmad (American University of Beirut, Lebanon) and colleagues isolated and characterized a novel E. phage, AUBRB02. They discuss po

    UpdatesResearch paperPhage isolation
  8. UpdatesJul 17, 2024

    Bacterial defence system conjugates ubiquitin-like proteins to phage tail fibres, impairing infectivity (Nature)

    A bacterial antiphage system made of a ubiquitin-like protein, E1 and E2 conjugating enzymes and a deubiquitinase attaches the ubiquitin-like protein to the phage central tail fibre during infection. Infected cells release tailless particle

    UpdatesPapersPhage Biology
  9. UpdatesJul 12, 2024

    Andreas Brödel (Eligo Biosciences) and colleagues have successfully edited E. coli genes in the mouse gut using engineered ph

    Andreas Brödel (Eligo Biosciences) and colleagues have successfully edited E. coli genes in the mouse gut using engineered phages. They used (non-replicative) phage to deliver a base editor, and achieved >90% modification without adverse ef

    UpdatesGut BacteriaGene EditingMice
  10. UpdatesJul 12, 2024

    Fereshteh Bayat (McMaster University) and colleagues have designed a high-throughput phage screening platform comprised of a

    Fereshteh Bayat (McMaster University) and colleagues have designed a high-throughput phage screening platform comprised of a portable library of individual shelf-stable, ready-to-use phages, in solid tablets that include a phage + luciferin

    UpdatesHigh throughputPhage susceptibility testMethod
  11. UpdatesJul 12, 2024

    Hannelore Longin (KU Leuven, Belgium) and colleagues have reviewed the emerging role of posttranslational modifications durin

    Hannelore Longin (KU Leuven, Belgium) and colleagues have reviewed the emerging role of posttranslational modifications during phage-bacteria interactions, highlighting their potential impact on protein behavior and suggesting a comprehensi

    UpdatesPhage-Bacteria InteractionsPosttranslational ModificationsEnzyme Discovery
  12. UpdatesJul 12, 2024

    Emma Spencer (University of Idaho) and colleagues published a new preprint on phages of honeybee pathogen Paenibacillus larva

    Emma Spencer (University of Idaho) and colleagues published a new preprint on phages of honeybee pathogen Paenibacillus larvae. They looked at resistance evolution and how phage resistant isolates developed reduced pathogenicity — and phage

    UpdatesPhage resistanceResearch paperPhage-host interactions
  13. UpdatesJul 12, 2024

    A recent meta-analysis reveals that infections are a major (>50%) cause of non-relapse-associated deaths following CAR-T cell

    A recent meta-analysis reveals that infections are a major (>50%) cause of non-relapse-associated deaths following CAR-T cell therapy.

    UpdatesNewsCAR-TInfections
  14. UpdatesJul 11, 2024

    On Nov 19-20, the International Alliance for Biological Standardization (Amsterdam, Netherlands) is hosting a virtual scienti

    On Nov 19-20, the International Alliance for Biological Standardization (Amsterdam, Netherlands) is hosting a virtual scientific workshop about the veterinary use of phages, specifically looking at quality, safety and efficacy. Speakers fro

    UpdatesCommunityStandardsVeterinary UseWorkshop
  15. UpdatesJul 11, 2024

    In a recent episode of the PhageCast podcast, Graham Hatfull (University of Pittsburgh) discusses the importance of mycobacte

    In a recent episode of the PhageCast podcast, Graham Hatfull (University of Pittsburgh) discusses the importance of mycobacteriophages and their potential for phage therapy against M. abscessus.

    UpdatesCommunityPodcastPhage TherapyMycobacterium abscessus
  16. UpdatesJul 11, 2024

    IPATH is calling for labs to help find Achromobacter phages for an upcoming clinical trial for cystic fibrosis with phage the

    IPATH is calling for labs to help find Achromobacter phages for an upcoming clinical trial for cystic fibrosis with phage therapy, inviting contributions and further information via email at ipath@health.ucsd.edu.

    UpdatesCommunityAchromobacterClinical TrialCystic Fibrosis
  17. UpdatesJul 11, 2024

    Cytophage Technologies Ltd. have shared the recording of their first investor call since becoming a public company.

    Cytophage Technologies Ltd. have shared the recording of their first investor call since becoming a public company.

    UpdatesCommunityBiotech newsCommercializationPhage therapy
  18. UpdatesJul 11, 2024

    Shelf-stable phage tablets with a bioluminescent reporter enable high-throughput phage screening (Nature Communications)

    A portable library of solid tablets, each encapsulating one phage with luciferin and luciferase stabilized in a pullulan-trehalose sugar matrix, detects phage-mediated ATP release as light when bacterial cells burst. The platform identified

    UpdatesPapersDiagnostics
  19. UpdatesJul 10, 2024

    Anti-CRISPR regulator Aca2 binds both DNA and RNA to control phage anti-CRISPR production (Nature)

    The helix-turn-helix regulator Aca2 represses phage anti-CRISPR synthesis transcriptionally by binding DNA and also inhibits translation of the mRNAs by binding conserved RNA stem-loops and blocking ribosome access; a cryo-EM structure of t

    UpdatesPapersPhage Biology
  20. UpdatesJul 5, 2024

    The DOE Joint Genome Institute (JGI) is hosting the "VEGA 2024: Viral EcoGenomics and Applications" symposium, taking place o

    The DOE Joint Genome Institute (JGI) is hosting the "VEGA 2024: Viral EcoGenomics and Applications" symposium, taking place on November 12-13, 2024, in Berkeley, California. The symposium aims to bring together the viral ecogenomics communi

    UpdatesCommunityViral EcoGenomicsPhage ApplicationsIMG/VR
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