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Researchers at the University of Minho and partner institutions show that synthetic M13 phages displaying Aβ-derived peptides bind preferentially to amyloid-β oligomers. In hippocampus tissue from APP/PS1 transgenic mice the phages detected

In this preprint, intravenously administered antipseudomonal phage LPS-5 had blood half-lives of 3.45 and 3.66 hours in wild-type and neutropenic mice, suggesting neutrophil phagocytosis is not a major driver of phage clearance. A gap betwe

Researchers at the Institute of Oceanology, Chinese Academy of Sciences cultured a novel deep-sea cold-seep Planctomycetes strain, ZRK32, which they propose to name Poriferisphaera heterotrophicis. Supplementing nitrate or ammonium induced

A review of in vitro attempts to use bacteriophages and their enzymes, alone or together with antibiotics and other agents, against polymicrobial biofilms, including some therapeutic uses. It also sums up the advantages, disadvantages and p

A Nature Microbiology study from the Universities of Würzburg and Tübingen shows that in Vibrio cholerae the CBASS anti-phage signalling system increases sensitivity to antifolate antibiotics up to tenfold and enables bacterial lysis by the

A Nature Communications study (open access) describes Paride, a newly isolated Pseudomonas aeruginosa phage that can replicate directly in, and lyse, deep-dormant host cells, whereas other phages tested suspended replication until the host

The recombinant endolysin LysAB1245, from phage T1245, showed broad activity against all clinical multidrug-resistant A. baumannii isolates tested across capsular types KL2, 3, 6, 10, 47, 49 and 52, with a reduction of more than 3 log in vi

University of Arizona researchers, with a co-author from Reckitt (Lysol and Dettol), flushed household and public toilets seeded with bacteriophage MS2, a surrogate for human enteric viruses. Contamination of restroom surfaces did not depen

Researchers at the University of California, Berkeley developed a CRISPR interference method to map gene essentiality in phages and applied it to the coliphages λ and P1, largely recapitulating the known essential genes of λ and giving new

Researchers at KIST Europe genetically modified filamentous fd phages to display shortened versions of a Cu(II)-specific peptide (HGFANVA). ICP-MS analyses showed improved Cu(II) binding by the engineered phages compared with wild-type fd,

Researchers at the University of Maryland Baltimore County describe two satellite-helper phage systems infecting Streptomyces species, which they call the first examples of bacteriophage satellite viruses. The Flayer satellite does not appe

The 2023 PhageScope paper describes a database with 873,718 phage sequences and annotations for genome completeness, hosts, lifestyle, taxonomy and genetic elements, plus automated analyses and visualizations. Oxford Academic

Lund University researchers used contrast-matching small-angle neutron scattering to show that DNA packaged in the phage λ capsid undergoes a density and volume transition in the core as temperature rises from 20 °C to 40 °C, close to the p

Stanford researchers show that the temperate filamentous phage Pf4 of Pseudomonas aeruginosa is decorated with outer membrane vesicles whose short RNAs trigger TLR3-dependent type I interferon production and suppress antibacterial cytokines

Monash University researchers applied highly purified phage T4 to mammalian cells in vitro and found it was rapidly internalized into macropinosomes without activating the TLR9 or cGAS-STING DNA-sensing pathways. T4 instead activated AKT-de

Researchers at Skoltech report the full genome sequence and virion protein content of Escherichia coli phage BF23, a close relative of T5 that was isolated in the mid-twentieth century. BF23 resists Types I/II/III restriction-modification s

Singapore University of Technology and Design researchers combined M13-conjugated polyethylene glycol with tungsten disulfide nanosheets to build a Phage-based Digital Biomolecular Sensor (P-DBS) for MCF-7 cancer cells. The sensor reached a

Researchers led from the Ocean University of China characterised Halomonas phage vB_HmeY_H4907, isolated from surface sediment of the Mariana Trench at a depth of 8,900 m. The authors describe it as the deepest isolated siphovirus from the

University of California, Berkeley researchers report the first observation of heat-induced electrical potential generation on a virus, studying the pyroelectric properties of the M13 phage. Modifying the pVIII coat protein with different n

Researchers at the World Institute of Kimchi found that Pediococcus inopinatus is generally dominant in Mukeunji, long-term fermented kimchi in the final stage of fermentation. Its genome has a well-developed CRISPR system with an extra cop