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Engineering phages is getting more popular; here's another breakthrough in phage synthetic biology! Matthew Dunne (ETH Zurich) and colleagues have developed several approaches for engineering phages targeting Gram-positive pathogens (using

Is lyophilization a good way to store phages? Prasanth Manohar and Nachimuthu Ramesh (Vellore Institute of Technology) tested lyophilization conditions for three phages (an Escherichia phage, a Klebsiella phage and an Enterobacter phage) us

Jeffrey Carey (University of Pennsylvania) and colleagues have shown that a temperate E. coli phage reprograms its host's regulation of an anaerobic respiratory system. They found that the prophage disables the bet-hedging strategy that aid

Jeffrey Carey (University of Pennsylvania) and colleagues have shown that a temperate E. coli phage reprograms its host's regulation of an anaerobic respiratory system. They found that the prophage disables the bet-hedging strategy that aid

We collectively don’t know much about how phages work in cocktails, or how best to optimize phage therapy when multiple phages are combined. Rosanna Wright (University of York) and colleagues have shown, using P. aeruginosa and pairs of pha

Marta Lourenço (Institut Pasteur) and colleagues have published a preprint on how inaccessible sites in the mouse gut mucosa serve as a spatial refuge for bacteria, limiting phage predation, and leading to phage-bacterial coexistence that i

Marta Lourenço (Institut Pasteur) and colleagues have published a preprint on how inaccessible sites in the mouse gut mucosa serve as a spatial refuge for bacteria, limiting phage predation, and leading to phage-bacterial coexistence that i

New research by Andrey Shkoporov and colleagues at APC Microbiome in Ireland has shown using longitudinal metagenomics that the human gut virome is actually very stable in individuals, but that each individual tested had their own unique vi

Siobhán O'Brien of the University of Liverpool and colleagues published a paper showing how transposable prophages lead to P. aeruginosa adaptation. They alter iron availability to show that transposable prophages cause P. aeruginosa to evo

Siobhán O'Brien of the University of Liverpool and colleagues published a paper showing how transposable prophages lead to P. aeruginosa adaptation. They alter iron availability to show that transposable prophages cause P. aeruginosa to evo

New research by Andrey Shkoporov and colleagues at APC Microbiome in Ireland has shown using longitudinal metagenomics that the human gut virome is actually very stable in individuals, but that each individual tested had their own unique vi

We collectively don’t know much about how phages work in cocktails, or how best to optimize phage therapy when multiple phages are combined. Rosanna Wright (University of York) and colleagues have shown, using P. aeruginosa and pairs of pha

Kevin Yehl of MIT and colleagues have developed a high-throughput strategy to genetically engineer host range-determining regions within phage tail fiber proteins to create libraries of millions of phages with different receptor binding cap

Sara Clifton of the University of Illinois at Urbana-Champaign and colleagues have used population modeling to examine the role of latent prophages in bacterial populations in response to antibiotic treatment. They show that antibiotics can

Sara Clifton of the University of Illinois at Urbana-Champaign and colleagues have used population modeling to examine the role of latent prophages in bacterial populations in response to antibiotic treatment. They show that antibiotics can

Kevin Yehl of MIT and colleagues have developed a high-throughput strategy to genetically engineer host range-determining regions within phage tail fiber proteins to create libraries of millions of phages with different receptor binding cap

Dr. Christine Rohde I recently accepted to serve as Guest Editor for the Special Issue “Phage Diversity for Research and Application” of the journal Antibiotics. I would be very pleased if you agreed to contribute a research paper, or a com

Jolien Onsea and colleagues from KU Leuven, University Hospitals Leuven, and the Queen Astrid Military Hospital in Belgium successfully used phage therapy to treat four patients with severe musculoskeletal infections. Importantly, the autho

Hans Duyvejonck and colleagues at Ghent University and the Queen Astrid Military Hospital in Belgium have published a paper evaluating the use of qPCR to quantify 5 phages within a cocktail. They compared qPCR to plaque assays, and showed t

Wolbachia are bacteria that are transmitted among female arthropods, sometimes killing males of their hosts. Jessamyn Perlmutter of Vanderbilt University and colleagues have shown that a single Wolbachia prophage gene may be responsible for