Search

HepS, encoded by the Gifsy-1 prophage in Salmonella enterica serovar Typhimurium, detects infection by Siphoviridae phages and cleaves tRNA anticodon loops to halt phage replication. Gifsy prophages evade self-targeting through a tail-tip v

Helena Shomar from Institut Pasteur and colleagues identified over 2000 lanthipeptide biosynthetic gene clusters in Actinobacteria with anti-phage defense properties, which they termed "lanthiphages". These clusters, often found in defense

Pramalkumar Patel (University of Toronto) and colleagues uncovered a novel anti-phage defence mechanism, where the P. aeruginosa prophage protein Tab blocks phage tail assembly, preventing formation of infectious virions.

Matthew C Johnson and colleagues have shown that Pseudomonas aeruginosa exhibits the greatest diversity of anti-phage systems among 30 species. They identified two core defense hotspot loci (cDHS1 and cDHS2) where many anti-phage immune sys