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The study presents DepoCatalog, an experimentally validated collection of 129 recombinantly prepared Klebsiella phage depolymerases across 75 KL-types, and proposes a five-class framework for their diversity. The accompanying DepoCat databa

Nadezhda Kolupaeva (State Research Center for Applied Microbiology and Biotechnology, Russia) and colleagues published a new paper on diverse prophage content in A. baumannii and K. pneumoniae bloodstream isolates from patients in the ICU,

Paper: Phage-mimicking nanoagents for rapid depolymerase specificity screening against multidrug resistant bacteria.

The paper introduces PhageDPO, a machine-learning tool available in Galaxy for identifying depolymerases in phage and prophage genomes. The authors say the source code is on GitHub. Computers in Biology and Medicine article

The recombinant PRA33gp45 hydrolysed K27 capsule polysaccharides and inhibited biofilm formation, disrupted mature biofilms, and altered biofilm architecture. In a Galleria mellonella larvae model, PRA33gp45 treatment lowered morbidity and