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Svenja Thöneböhn (Justus-Liebig-Universität Gießen, Germany) and colleagues have identified new components of the Shewanella phage LambdaSo lysis system, including a pinholin/signal-anchor-release (SAR) endolysin system and a two-component

Yves Briers will head up Obulytix, a new company based on the phage lysin-based platform leveraging AI to tackle bacterial infections he co-developed at Ghent University and KU Leuven. Obulytix has already attracted $4 M Euro investment fro

Contrafect, a company developing ‘direct lytic agents’ (which include lysins and amurin peptides), has submitted an IND application for preliminary approval of a new IV antibacterial agent for treatment of hospital-acquired and ventilator-a

Postdoctoral position available at Rockefeller University working on phage lysins. Only considering applicants currently in USA. PhD or MD. Proficiency in protein chemistry, molecular biology, and protein purification a must. Send applicati

Shakhinur Islam Mondal (APC Microbiome Ireland) and colleagues published a new paper in International Journal of Molecular Sciences that characterizes a Clostridioides difficile-specific endolysin that affects spore outgrowth.

Courtney Davies (Massey University, New Zealand) and colleagues published a new paper in Frontiers in Microbiology showing that Mycobacteriophage endolysins can kill Mycobacteria when fused to 'PLAN-M' biodegradable nanobeads, which can be

Fazal Mehmood Khan (Chinese Academy of Sciences) and colleagues published a research paper on a novel endolysin isolated from an Acinetobacter baumannii phage with high antibacterial activity against multiple gram-negative microbes. The nov

Fatma Abdelrahman (Zewail City of Science and Technology, Egypt) and colleagues from 7 countries (Egypt, India, Nigeria, Australia, China, Pakistan, Spain), many of them early career researchers, published a new review in Antibiotics on pha

Athina Zampara (University of Copenhagen, Denmark) and colleagues published a new paper in Frontiers in Microbiology on developing innolysins (endolysins fused to phage receptor binding proteins) against Campylobacter jejuni using a novel p

PhagoMed's synthetic phage lysin platform for treatment of bacterial vaginosis came in second place (and won 20,000 Euro) in the European Institute of Innovation and Technology's 2020 Health Catapult contest.

Dutch phage biotech company Micreos has signed a license agreement with L'Oréal — this means L'Oréal can incorporate Micreos' phage lysins into its products, and represents a huge milestone for phage biotech making its way into the mainstre

There is currently no working treatment for recurring bacterial vaginosis (BV). Christine Landlinger (PhagoMed Biopharma GmbH) and colleagues published a new preprint in medRxiv showing that their engineered phage endolysin candidate elimin

Emily’s Entourage, a nonprofit organization that funds cystic fibrosis research and drug development, has funded four new grants (totaling $790,000 over two years), two of which are phage-related. One was awarded to IPATH researchers to dev

Niels Vander Elst (Ghent University) and colleagues published a new paper in Antibiotics on the characterization of two phage lysins, PlySs2 and PlySs9, which have in vitro lytic activity against bovine mastitis pathogen Streptococcus uberi

Karim Abdelkader (Ghent University) and colleagues published a new paper in Applied and Environmental Microbiology showing that an Acinetobacter baumannii phage lysin has a turgor pressure-dependent intrinsic antibacterial activity and can

Athina Zampara (University of Copenhagen) and colleagues published a new paper in Scientific Reports on the use of phage receptor binding proteins to enable endolysins ("Innolysins") to kill Gram-negative bacteria.

International Bacteriophage Research Consortium International Bacteriophage Research Consortium (IBRC), created by Open Health Systems Laboratory (OHSL), USA and Acharya Narendra Dev College (ANDC), University of Delhi, India is organizing

Hans Gerstmans (Ghent University, Belgium) and colleagues published a new paper in Science Advances on a VersaTile-driven platform for rapid hit-to-lead development of engineered lysins. Stay tuned; next week's feature article will be a beh

Steven Swift (Beltsville Agricultural Research Center) and colleagues have engineered a chimeric phage lysin that lyses Clostridium perfringens, an important poultry pathogen. They fused the cell wall binding domain of a C. perfringens phag

Steven Swift (Beltsville Agricultural Research Center) and colleagues have engineered a chimeric phage lysin that lyses Clostridium perfringens, an important poultry pathogen. They fused the cell wall binding domain of a C. perfringens phag