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This review surveys more than 80 phage bioinformatics tools for identification, assembly, annotation, taxonomy, lifestyle, defence, and host prediction. It compares sequence homology, machine learning, and foundation-model approaches, then

A Nature Communications Review by Sam P. B. van Beljouw and Li Yuping (Biozentrum, University of Basel) on jumbo bacteriophages, whose double-stranded DNA genomes exceed 200 kb. It covers their diversity, evolutionary origins, distinctive m

A Nature Communications Perspective by Aleksandra Petrović-Fabijan and Stephen T. Abedon argues that phage therapy must move beyond anecdote to clinical reproducibility, and identifies three foundational pillars to be addressed through inte

A perspective arguing that traditional bacteriophage methods measure population averages and miss variation between individual particles. It advocates optical microscopy and flow cytometry approaches that can reveal phenotypic heterogeneity

Terlizzi and colleagues report a systematic review in the International Journal of Infectious Diseases of phage therapy in cystic fibrosis: 19 studies covering 51 patients and 52 phage treatment courses, mostly against Pseudomonas aeruginos

Contagion Live article by Amer El-Ghali and Dana Holger reviewing phage-antibiotic combinations (PACs) in refractory multidrug-resistant infections: preclinical synergy is consistent and compassionate-use reports show safety and frequent cl

Review by Choudhary, Bankole, McDuffee, Parajuli, Poudel, Balogh, Paret and Jones in Viruses on bacteriophages as biocontrol agents against plant bacterial diseases, as an alternative to antibiotics. It discusses barriers to implementation

Review by Feng et al. in Precision Clinical Medicine on the human gut virome, 90%-95% of which is phages. It examines how the virome develops and how diet, environment, host genetics and immunity shape it, its associations with various dise

Chase Morgan (University of California San Diego), Haley Atkins (Loyola University Chicago) and colleagues published a new review on phage therapy for urinary tract infections, showing phage therapy for this indication is promising, but nee

Xiaolin Hou (Chinese Academy of Sciences) and colleagues published a new paper on advances in engineered phages for disease treatment, showing recent progress in enhancing phage targeting, stability, and synergistic combinations, across ant

A review of recent advances in using bacteriophages to treat the most common bacterial infectious diseases of cultured fish, shellfish and crustaceans. It concludes that the documented research supports phage therapy in aquaculture but that

José Penadés (Imperial College London) and colleagues published a new review on phage satellite genetics, ecology and evolution, diving into how these elements impact bacterial evolution and virulence.

Phage cocktail or personalized therapy — an age-old binary, or a spectrum after all? Minyoung Kevin Kim (Stanford University) and colleagues from Mayo Clinic, QAMH, & KU Leuven published a review on how phage therapy is currently being impl

Are you my host? Paul Hyman (Ashland University) published a new paper on methods for linking phages with hosts, showing growth-based, genome sequence-based, and proximity-based approaches each measure different aspects of phage-host intera

This review surveys phage genomics, phage–host interactions, and medical and biotechnological applications, including mechanisms and therapeutic uses in infections involving virus–bacteria interactions. www.mdpi.com

Talia Backman (University of Utah) and colleagues published a new paper on tradeoffs and constraints in tailocin evolution, showing tailocins exhibit extreme target specificity, evolve rapidly, and face tradeoffs between resistance and host

William Summers has authored a new review on how the Cold War geopolitical climate in the US contributed to the decline of phage therapy, while it thrived in Eastern Europe.

Niels Vander Elst (Karolinska Institute, Sweden) has reviewed the potential of phage-derived endolysins against bovine mastitis caused by streptococci and staphylococci, highlighting recent progress in engineering endolysins for robust acti

Phage banks are fragmented, and it’s time to unify them, according to a new review led by Gregory Resch (University of Lausanne) and including authors from Felix d’Herelle Center and DSMZ, two major phage repositories.

Paul Turner (Yale University) and colleagues have written a new review on gaps in modern phage therapy R&D. It includes some fun exploration of how AI & synbio could ease phage therapy logistics, a walkthrough of how and why new funding & r