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Phage researchers can now access PhageBox, an open-source digital microfluidic extension that integrates temperature and electromagnetic modules, which can be used for phage research, as recently demonstrated by Dreycey Albin (University of

Thilo Köhler (Geneva University Hospitals) and colleagues report successful treatment of a 41-year-old patient with a P. aeruginosa infection using aerosolized phage therapy. They followed evolution of phage and bacteria in respiratory samp

Mariam Taha (Ottawa Hospital Research Institute) and colleagues have published a study on the efficacy of lytic phages combined with vancomycin against S. aureus biofilm-like aggregates in synovial fluid, offering a promising strategy again

Anisha Thanki (University of Leicester, UK) and colleagues have shown that a phage cocktail delivered in chicken feed significantly reduced Salmonella colonization in experimentally-challenged broiler chickens.

Ming Hu (Qingdao University, China) and colleagues have isolated and characterized two novel, highly pH- and temperature-stable jumbo phages and found they have strong potential to eliminate Klebsiella pneumoniae in sewage water.

David Helekal (University of Warwick, UK) and colleagues have published a new model to estimate AMR fitness cost and benefit. They found that two unrelated Neisseria gonorrhoeae lineages resistant to fluoroquinolones shared similar epidemic

Naomi Haddock (Stanford University, USA) and colleagues have developed a pipeline to identify phages and their bacterial hosts in cell-free DNA from plasma samples, enabling identification of bacterial pathogens associated with sepsis.

A new paper published in Microbiology Spectrum by Magdalena Unterer (Helmholtz Centre Munich) describes a high-throughput method for identifying and characterizing phages for phage therapy, revealing cell-to-cell variations in phage kinetic

Elliot Macdonald and colleagues at Newcastle University have identified a new anti-phage system called Shield, found in Pseudomonas, made of a core component ShdA and a membrane-bound protein with an RmuC domain, which provides a new mechan

Maria Villalba (Ecole Polytechnique Fédérale de Lausanne, Switzerland) and colleagues describe in PNAS their new optical nanomotion method to test single-bacterium viability and antibiotic response in 1-2 hours using a basic microscope, a c

Primary sclerosing cholangitis (PSC) is a chronic, progressive liver disease. Masataka Ichikawa (Keio University, Japan) and colleagues from BiomX have shown in a new paper that oral and oral+IV administration of a phage cocktail supresses

Thu Vu Phuc Nguyen and colleagues have a new preprint showing that when multiple phages infect the same cell, they slow or even prevent each other from entering the cell. Check out his Twitter thread!

Sabrina Green and colleagues published a retrospective observational study of 12 cases of expanded access customized phage therapy. They found that customized phage production and therapy was safe and yielded favorable clinical or microbiol

In a new preprint, Ritam Das and colleagues have systematically characterized the genomic characteristics, lifestyle, and potential therapeutic applications of ten B1 sub-cluster mycobacteriophages. They predicted the function of 55% of the

In the arms race between bacteria and phages, some large-genome jumbo phages have evolved a protein shell that encloses their replicating genome. In a new preprint, Eray Enustun and colleagues have used proximity labeling to identify a ‘pha

Phage utility against Burkholderia cepacia complex species has been restricted by the prevailing paradigm of only using rare, obligately lytic phages, due to the perception that lysogenic phages are therapeutically unsuitable. Philip Lauman

Temperate phages drive bacterial genome evolution and impact human health. In a new paper, Justin Silpe and colleagues explore interprophage competition during polylysogeny, shedding light on induction mechanisms and strategies.

David Wishart and colleagues have introduced PHASTEST (PHAge Search Tool with Enhanced Sequence Translation) as a faster and more accurate web server for annotating prophage sequences and bacterial genomes. In standardized tests, PHASTEST o

This paper by Samuel Barnett and Daniel Buckley explores the role of soil viruses in the carbon cycle. They added 13C-labelled carbon sources to soil and used metagenomic-SIP to detect 13C assimilation by viruses and their putative hosts. T

A new ISME Journal article by Xiang Tang and colleagues shows lysogenic phages with arsM-bearing markers help bacterial communities adapt to trivalent arsenic toxicity. The phage-host interaction enabled the quick spread of arsM among soil