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PHAGE4DAIR, a Horizon Europe project coordinated by Qeen Biotechnologies (Canada), runs from 1 June 2026 to 31 May 2031 with an EU contribution of €14,869,038.73. It is a multicenter, randomized, double-blind, placebo-controlled, adaptive P

Using the Klebsiella podophages KP32, K11 and KP34, the authors validated the interaction between the primary RBP branching domain and the secondary RBP docking peptide. They used this interaction to engineer a KP32 scaffold that propagated

Biochemistry, cryo-electron microscopy and single-molecule imaging show that Hna, a broadly distributed anti-phage system that triggers abortive infection, is a 3'-5' single-stranded DNA exonuclease forming an auto-inhibited dimer under phy

A structural and functional study of QatB and QatC, two components of the four-protein QatABCD anti-phage defense system. QatC bound to the ATP analog AMPPNP and the QatB-QatC heterodimer were solved, and structural analysis suggests QatB m

More than two-thirds of Streptococcus thermophilus strains harbor a phage satellite structurally similar to Staphylococcus aureus pathogenicity islands (SaPIs). Virulent phages can trigger induction of these satellites, and their DNA can th

A metagenomic study of 450 virus-enriched honey bee gut samples from 63 hives across eight European countries, three seasons and three gut sections catalogues a diverse phageome, including many phages that appear to belong to novel taxa and

A Nature Communications Perspective by Aleksandra Petrović-Fabijan and Stephen T. Abedon argues that phage therapy must move beyond anecdote to clinical reproducibility, and identifies three foundational pillars to be addressed through inte

Lytic selection and evolution (LySE) is a T7-based method for near-continuous directed evolution of bacterial gene clusters that keeps discrete checkpoints: a hypermutagenic T7 DNA polymerase mutates a target gene cluster carried on a T7 ph

V-score and VL-score are annotation-free metrics that quantify the "virus-likeness" of protein families and genomes, released with an open-access searchable database, V-Score-Search. Applied to public protein databases they link 19-59% of p

A high-throughput droplet microfluidics platform co-encapsulates individual phages and bacteria to quantify single phage infection events, with control over exposure time and the phage-to-bacteria ratio. It measures lysis events and lysis k

The study links temperate-phage capsule specificity with diverse receptor-binding proteins, including classical depolymerases and SGNH-domain hydrolases predicted to deacetylate polysaccharides. The team also shared English and Polish comic

Large-scale comparative cell biology and biochemistry of 16 bacterial nuclease-NTPase antiphage defence systems shows that protein-protein complex formation is a shared feature. The nucleases of the Pa AbpAB, Bt Hachiman and Ec PD-T4-8 syst

A perspective arguing that traditional bacteriophage methods measure population averages and miss variation between individual particles. It advocates optical microscopy and flow cytometry approaches that can reveal phenotypic heterogeneity

Terlizzi and colleagues report a systematic review in the International Journal of Infectious Diseases of phage therapy in cystic fibrosis: 19 studies covering 51 patients and 52 phage treatment courses, mostly against Pseudomonas aeruginos

VirHost Hunter uses phage tails and lysins with protein language models and vision transformers to assign hosts without requiring complete phage genomes. High-resolution phage-host assignment through key proteins using large language models

Godsil, Wei and Meeske report in Nature Microbiology that the Listeria seeligeri type VI-A CRISPR system restricts the lytic cycle of temperate phages but tolerates prophage acquisition and interferes with prophage induction through a non-a

A Bioengineering & Translational Medicine study from the University of Sydney spray-dried phage PEV1 with polyvinylpyrrolidone (PVP) grades K15 to K100 and stored it for 180 days at 4, 22 and 40 °C and 15 to 53% relative humidity. At 33% re

Damgaard and colleagues report in Communications Medicine that Bacteroides fragilis isolates from colorectal cancer (CRC) patients are infected with specific Caudoviricetes prophages significantly more often than controls, a finding made by

Patel and colleagues describe in Nature a 164-residue prophage-encoded defence protein, ring interacting pore 1 (Rip1), that is activated by the portal or small terminase proteins of infecting phages, oligomeric ring-shaped complexes essent

An automated screening platform combining liquid-handling robotics, standardized phenotypic assays and computer-vision enumeration screens large phage collections against clinical bacterial strain panels and has assessed more than 3.8 milli