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  • Phage prohead proteases activate CBASS antiphage immunity (Science)

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  1. UpdatesOct 25, 2024

    Phage Hunters Training and Research Program has announced a fundraising campaign to support phage research training in Africa

    Phage Hunters Training and Research Program has announced a fundraising campaign to support phage research training in Africa. The initiative aims to equip young scientists with bioinformatics skills for in-silico phage hunting to combat an

    UpdatesCommunityFundraisingTraining
  2. UpdatesOct 25, 2024

    New phage book alert! Lina Zeldovich announced that her new book, "The Living Medicine," is out today, described by reviewers

    New phage book alert! Lina Zeldovich announced that her new book, "The Living Medicine," is out today, described by reviewers as “unputdownable” and compared to "The Immortal Life of Henrietta Lacks," making it a must-read for those interes

    UpdatesCommunityBookPhage therapyHistory
  3. UpdatesOct 25, 2024

    NIAID has announced a new $6M funding opportunity to establish Centers for Accelerating Phage Therapy to combat ESKAPE pathog

    NIAID has announced a new $6M funding opportunity to establish Centers for Accelerating Phage Therapy to combat ESKAPE pathogens. This is the first major NIH phage therapy-specific center-level grant. By this time next year, 2-3 phage ther

    UpdatesFunding opportunityPhage therapy
  4. UpdatesOct 25, 2024

    Achaogen's 2019 bankruptcy led to the loss of plazomicin, a promising aminoglycoside. John Rex and Kevin Outterson have analy

    Achaogen's 2019 bankruptcy led to the loss of plazomicin, a promising aminoglycoside. John Rex and Kevin Outterson have analyzed the financial failure of plazomicin and Achaogen, summarizing key findings from a post-mortem study. Their con

    UpdatesBiotechAntimicrobialsEconomics
  5. UpdatesOct 25, 2024

    Mihály Koncz (HUN-REN Biological Research Centre, Szeged, Hungary) and colleagues combined phylogeographic analysis with phag

    Mihály Koncz (HUN-REN Biological Research Centre, Szeged, Hungary) and colleagues combined phylogeographic analysis with phage typing to guide precision phage therapy, showing that a few carbapenem-resistant A. baumannii strain types domina

    UpdatesResearch paperPhage typingPhage therapy
  6. UpdatesOct 25, 2024

    Yunxue Guo (Chinese Academy of Sciences) and colleagues discovered a reverse transcriptase-mediated mechanism of prophage gen

    Yunxue Guo (Chinese Academy of Sciences) and colleagues discovered a reverse transcriptase-mediated mechanism of prophage genome reduction in P. aeruginosa biofilms, showing that Pf4 phage-encoded RT and an ncRNA collaborate to generate sup

    UpdatesResearch paperReverse transcriptaseProphages
  7. UpdatesOct 25, 2024

    Did you know the CDC and FDA have an Antimicrobial Resistance (AR) Isolate Bank? Researchers can order microbial isolates for

    Did you know the CDC and FDA have an Antimicrobial Resistance (AR) Isolate Bank? Researchers can order microbial isolates for free, collected from CDC's surveillance and outbreak activities. These isolates are combined into panels for testi

    UpdatesAMRIsolate BankPublic resource
  8. UpdatesOct 18, 2024

    Xin Hou (Sun Yat-sen University, China) and colleagues published a new paper on using AI to expand the diversity of the globa

    Xin Hou (Sun Yat-sen University, China) and colleagues published a new paper on using AI to expand the diversity of the global RNA virosphere, showing 161,979 putative RNA virus species and 180 RNA virus supergroups identified in diverse gl

    UpdatesRNA virosphereRNA viruses
  9. UpdatesOct 18, 2024

    Tetrapyrroles such as heme, chlorophyll, and vitamin B12 are essential for various metabolic pathways. Helen Wegner (Universi

    Tetrapyrroles such as heme, chlorophyll, and vitamin B12 are essential for various metabolic pathways. Helen Wegner (University of Kaiserslautern-Landau, Germany) and colleagues demonstrated the presence of tetrapyrrole genes in phage seque

    UpdatesMetabolismResearch paper
  10. UpdatesOct 18, 2024

    Stephano Iglesias (Thomas Jefferson University, Philadelphia) and colleagues created a high-resolution structural atlas of Ps

    Stephano Iglesias (Thomas Jefferson University, Philadelphia) and colleagues created a high-resolution structural atlas of Pseudomonas phage Pa193 using bioinformatics, proteomics, and cryogenic electron microscopy single particle analysis.

    UpdatesResearch paperStructural biology
  11. UpdatesOct 18, 2024

    David Mayo-Muñoz (University of Otago, New Zealand) and colleagues identified noncoding RNAs as key players in bacteria–phage

    David Mayo-Muñoz (University of Otago, New Zealand) and colleagues identified noncoding RNAs as key players in bacteria–phage conflicts, showing their roles in bacterial immunity and anti-defense mechanisms.

    UpdatesResearch paperNoncoding RNAsBacterial immunity
  12. UpdatesOct 18, 2024

    Nawal Al Aazi (Gaziantep University, Turkey) and colleagues identified clinical Pseudomonas Pf phages inducible by mitomycin

    Nawal Al Aazi (Gaziantep University, Turkey) and colleagues identified clinical Pseudomonas Pf phages inducible by mitomycin and investigated Pf1 phage, showing the presence of Pf1 phage associated with antibiotic effects.

    UpdatesTemperate phageInduction
  13. UpdatesOct 18, 2024

    Plasma-activated water pre-treatment enhances phage activity against Proteus mirabilis biofilms (Biofilm)

    Researchers at Queen's University Belfast and University College Dublin found that combining cold plasma-activated water with phage vB_PmiS_PM-CJR reduced biofilm-embedded Proteus mirabilis cells by about 4 log, as a possible option for cat

    UpdatesPapersPhage Therapy
  14. UpdatesOct 11, 2024

    ISVM members are invited to participate in the upcoming elections for the ISVM Executive Board, with voting taking place from

    ISVM members are invited to participate in the upcoming elections for the ISVM Executive Board, with voting taking place from October 7th to 21st, 2024, to shape the future of the organization and its initiatives in viruses of microbes rese

    UpdatesCommunityISVMElections
  15. UpdatesOct 11, 2024

    A new 'evolutionary trained' phage cocktail exploits resistance tradeoffs to target P. aeruginosa biofilms with enhanced effi

    A new 'evolutionary trained' phage cocktail exploits resistance tradeoffs to target P. aeruginosa biofilms with enhanced efficacy without triggering dual-phage resistance.

    UpdatesPhage cocktailsBiofilms
  16. UpdatesOct 11, 2024

    PlzR inhibits type IV pili assembly in P. aeruginosa and prevents phage infection.

    PlzR inhibits type IV pili assembly in P. aeruginosa and prevents phage infection.

    UpdatesPhage-host interactionsPhage receptors
  17. UpdatesOct 11, 2024

    A new perspective piece highlights how phages, phage-derived proteins and organic acids offer potential as biocontrols for fr

    A new perspective piece highlights how phages, phage-derived proteins and organic acids offer potential as biocontrols for fruit crop pathogens (especially P. syringae pathovars actinidiae and syringae, which attack kiwifruit and stone frui

    UpdatesOpinionPhage in agriculture
  18. UpdatesOct 11, 2024

    An array of anti-defence systems have been discovered in the ‘leading region’ of plasmids (the first to enter the cell), reve

    An array of anti-defence systems have been discovered in the ‘leading region’ of plasmids (the first to enter the cell), revealing their substantial role in evading bacterial immunity during conjugation. (Not phage exactly, but lots to lear

    UpdatesAnti-defensePlasmids
  19. UpdatesOct 11, 2024

    Qeen Biotechnologies (Gatineau, Quebec) has announced the opening of its new 4,800 sq ft manufacturing facility designed for

    Qeen Biotechnologies (Gatineau, Quebec) has announced the opening of its new 4,800 sq ft manufacturing facility designed for phage production, with operations starting as of September 2024.

    UpdatesBiotech newsPhage manufacturing
  20. UpdatesOct 9, 2024

    Phage communities in toothbrush and showerhead biofilms correlate with their bacterial hosts (Frontiers in Microbiomes)

    Querying 34 toothbrush and 92 showerhead metagenomes, researchers identified 22 complete, 232 high-quality and 362 medium-quality viral OTUs, with viral richness correlating with bacterial richness. Low sequence similarity to references and

    UpdatesPapersPhage BiologyMicrobiome
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