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HepS, encoded by the Gifsy-1 prophage in Salmonella enterica serovar Typhimurium, detects infection by Siphoviridae phages and cleaves tRNA anticodon loops to halt phage replication. Gifsy prophages evade self-targeting through a tail-tip v

Sikkema and colleagues describe in PNAS an engineering platform for the phiKMV-like Pseudomonas aeruginosa phage 41S1 built on one-pot High Complexity Golden Gate assembly (HC-GGA): the genome is divided into synthesizable DNA fragments tha

P2D1 tailocin from Dickeya dadantii was active against nine Pseudomonas strains among 480 soil and rhizosphere isolates. Six susceptible, nonpathogenic strains mitigated Dickeya-induced soft rot on potato; three related P. tensinigenes isol

A PLOS Biology study by Huss, Chitboonthavisuk, Meger and colleagues reports the dynamics between T7 bacteriophage and Escherichia coli aboard the International Space Station: phage activity was initially delayed in microgravity but ultimat

An International Journal of Infectious Diseases case report from the Military University Hospital Prague describes a 60-year-old woman with chronic MRSA vertebral osteomyelitis and non-removable spinal instrumentation who received 35 intrav

Perfilyev and colleagues analysed 3.6 million bacterial genome assemblies from 1,226 species in Nature Microbiology and found 119,510 lytic phage genomes, which they call bacterial assembly-associated phage sequences, a roughly five-fold in

The transatlantic taskforce on antimicrobial resistance sets out research and regulatory priorities for phage therapy, including standardized susceptibility testing, experimental models, GMP and personalized-treatment criteria, and clearer

Silverman and colleagues used RIL-seq to map RNA–RNA interactions in Escherichia coli during phage lambda infection, reported in Molecular Cell, and identified a phage-encoded small RNA, PreS (phage replication enhancer sRNA), embedded in t

Silver nanoparticles templated by the Escherichia coli phage M13 showed unusually high potency against Gram-negative pathogens including E. coli, Pseudomonas aeruginosa and Vibrio cholerae in vitro, and elicited resistance more than 10-fold

Barril, Bardina and Cuadrado (Universitat Autònoma de Barcelona) propose a mathematical model of phage therapy with encapsulated bacteriophages in the gastrointestinal tract. Microcapsules protect phages from degradation in acidic environme

Biofilm-adapted mutants of Pseudomonas phage PE1, evolved on a cystic fibrosis-derived P. aeruginosa isolate, controlled biofilms better in vitro under conditions mimicking the CF lung. Mutations in tail fiber and baseplate genes improved a

Bacteriophage T4 capsid nanoparticles arrayed with a CD4-binding DARPin or the HIV-1 gp140 envelope trimer reactivated HIV-1 latency in J-Lat T cell models and primary T lymphocytes without global T cell activation or cytokine storm, indepe

Paired bacterial and viral metagenomes from the guts of 49 individual honeybees, with a phage-bacteria interaction network built from CRISPR spacer matches and genome homology, show that viral and bacterial diversity are correlated, particu

A phage cocktail targeting Erwinia amylovora, the cause of fire blight, greatly reduced pathogen numbers and disease symptoms in inoculated pear flowers without significantly altering the resident floral microbiome (Holtappels, Wu, Koskella

Entelli-02 is a five-phage cocktail built from The Alfred Hospital's decade-long isolate collection against multidrug-resistant Enterobacter cloacae complex; it covers 88% of the hospital's 206 isolates and reduced bacterial load in septica

This guide helps researchers navigate tools for prophage detection, gene annotation, taxonomic classification, and downstream analysis. It highlights actively maintained tools available on the web or command line, including approaches for f

Zhang and colleagues, including Franklin Nobrega, report in Cell that the widespread two-component Kiwa defence system, a transmembrane sensor KwaA and a DNA-binding effector KwaB, assembles into a large membrane-associated supercomplex (cr

Review by Choudhary, Bankole, McDuffee, Parajuli, Poudel, Balogh, Paret and Jones in Viruses on bacteriophages as biocontrol agents against plant bacterial diseases, as an alternative to antibiotics. It discusses barriers to implementation

A phage display platform screens large libraries of chemically cyclized peptides carrying an affinity tag and a turn-on fluorescent reporter, so cleavage can be quantified in every selection round, to find selective substrates for a proteas

Jung and colleagues analysed the genomic, proteomic and functional characteristics of four bacteriophages (STP-1 to STP-4) targeting Salmonella Typhimurium, finding lysis-related genes (holin, endolysin, RZ-like spanins) and no genes linked