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Michael Schelling et al. published a new paper in PLOS Biology on how CRISPR-Cas effector specificity and cleavage site determine phage escape outcomes. They find that most pre-existing crRNA mismatches lead to phage escape, regardless of w

Justin M. Jenson et al. published a new paper in Nature entitled Ubiquitin-like Conjugation by Bacterial cGAS Enhances Anti-phage Defence. In the paper, the authors show that Cap2 forms a thioester bond with the C-terminal glycine of cGAS a

University of Exeter is recruiting a PhD student for a project that combines classical microbiology, microbial genetics and single cell microscopy to determine how bacterial defences evolve, and how they shape the spread of antimicrobial re

In a new paper in PNAS, Benoit Pons (University of Exeter) and colleagues show that antibiotics that target the protein translation machinery can alter the outcome of bacteria-phage interactions by interfering with the production of phage-e

Matthew Johnson (University of California, San Francisco) and colleagues have developed a computational tool to broadly identify anti-phage systems, which they applied to Pseudomonas aeruginosa genomes.

Brendan J. O’Hara (Tufts University School of Medicine) and colleagues published a paper in PLOS Genetics entitled The Vibrio cholerae Seventh Pandemic Islands act in tandem to defend against a circulating phage.

Artem Isaev (Skolkovo Institute of Science and Technology, Russia) and colleagues have published an article in Nucleic Acids Research on how the T7 phage DNA mimic protein Ocr inhibits the host BREX defense system. Ocr, which had been previ

Artem Isaev (Skolkovo Institute of Science and Technology, Russia) and colleagues have published an article in Nucleic Acids Research on how the T7 phage DNA mimic protein Ocr inhibits the host BREX defense system. Ocr, which had been previ

Beatriz Osuna (UCSF) and colleagues published two new papers this week in Cell Host & Microbe: one on how Listeria phages protect their lysogenic genomes by inducing Cas9 degradation and the other detailing how a bifunctional Listeria phage

Xiaolin Xiong (Wuhan University, China) and colleagues published their work on an unusual phosphorothioation-sensing bacterial defense system with broad anti-phage activities in Nature Microbiology.

Beatriz Osuna (UCSF) and colleagues published two new papers this week in Cell Host & Microbe: one on how Listeria phages protect their lysogenic genomes by inducing Cas9 degradation and the other detailing how a bifunctional Listeria phage

Xiaolin Xiong (Wuhan University, China) and colleagues published their work on an unusual phosphorothioation-sensing bacterial defense system with broad anti-phage activities in Nature Microbiology.