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Felix Croteau (McMaster University) and colleagues published a new paper on phage environmental DNA enhancing CRISPR adaptation, showing that free phage DNA in lysates increases phage-insensitive mutant generation through natural competence

David Sünderhauf (University of Exeter) and colleagues published a new paper on CRISPR-Cas in plasmid competition, showing CRISPR-Cas benefits plasmids defensively but is limited by competitor toxin-antitoxin systems when horizontally trans

Tina Liu’s lab at Rutgers University, New Jersey is hiring a postdoc to study molecular mechanisms of antiphage immunity in bacteria and archaea, focusing on the role and mechanism of CRISPR-associated nucleotide signaling.

Han Altae-Tran (Howard Hughes Medical Institute) and colleagues discovered over 200 new CRISPR-associated systems, including Cas14, an enzyme that cuts RNA precisely.

Y. Emre Gencay and colleagues have developed engineered phages with CRISPR-Cas machinery to reduce E. coli in mice. The phages, called SNIPR001, were well tolerated in mouse models and minipigs, and out-competed their ancestral wild-type ph

Michael Schelling et al. published a new paper in PLOS Biology on how CRISPR-Cas effector specificity and cleavage site determine phage escape outcomes. They find that most pre-existing crRNA mismatches lead to phage escape, regardless of w

In a new paper in Nature Microbiology, Benjamin Adler et al. show that the CRISPR-Cas13a protein from Leptotrichia buccalis has robust antiviral activity against a wide range of phages and can be applied as a generalizable tool for editing

This PhD project, co-supervised by Tiffany Taylor (University of Bath), Edze Westra (University of Exeter), and Andrew Preston (University of Bath), with collaborators Ben Ashby (Simon Fraser University) will study the interplay between a n

Frank Oechslin and colleagues published a paper in PLOS Biology entitled Phage endolysins are adapted to specific hosts and are evolutionarily dynamic. Using CRISPR-Cas9 genome editing, the authors found that phage endolysins could adapt to

In a new preprint on bioRxiv, Eligo Bioscience researchers engineer a phage-derived particle to deliver a base editor and modify E. coli colonizing the mouse gut.

Paper: Mucin induces CRISPR-Cas defense in an opportunistic pathogen.

Paper: Mucin induces CRISPR-Cas defense in an opportunistic pathogen.

Pre-print: RNA-targeting CRISPR-Cas13 provides broad-spectrum phage immunity

Paper: Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition — Tatiana Dimitriu et al

Paper: Type I CRISPR-Cas provides robust immunity but incomplete attenuation of phage-induced cellular stress.

North Carolina State University, NC is hiring a research scholar to develop methods in phage engineering, recombinant protein production, and CRISPR technologies.

Sooyeon Song (Pennsylvania State Universtiy, Pennsylvania) and colleagues published a preprint on how CRISPR-Cas controls cryptic prophages. They demonstrated that the E. coli CRISPR-Cas system is active and inhibits its nine defective prop

Xu Peng (University of Copenhagen, Denmark) is looking for a postdoc to work on CRISPR and anti-CRISPR of phages and archaeal viruses. Interested candidates may email the PI at peng@bio.ku.dk or DM her on Twitter (@XuPeng01770032).

CRISPR-Cas12j is a recently identified family of miniature RNA-guided endonucleases from phages. Arturo Carabias (University of Copenhagen) and colleagues published a new Nature Communications paper on the structure of CRISPR-Cas12j3. This

Xiaorong Wu (The Catholic University of America, Washington, DC) and colleagues published a new paper in mBio on how phage T4 escapes CRISPR attack by 'minihomology' (very short stretches of sequence identity) recombination and repair. This