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Benjamin Adler and colleagues have developed a broad-spectrum phage functional genomics platform using programmable RNA-binding protein dRfxCas13d, uncovering hidden infection strategies and predicting over 90 essential genes in phage genom

Justin Leavitt (University of Utah) and colleagues report that the P22-encoded SieA protein is the only phage protein required for exclusion by the SieA system, blocking DNA injection by P22 and its relatives, but having no effect on infect

Jens Hör (Weizmann Institute of Science) and colleagues have discovered that bacteria conjugate ubiquitin-like proteins to interfere with phage assembly.

Jean-Paul Pirnay at the Queen Astrid Military Hospital and colleagues published a new preprint on their center's first 100 cases of personalized phage therapy. They report clinical improvement in 77% of cases, and eradication of the target

Sofia Dahlman (Monash University, Australia) and colleagues characterized 125 active prophages from 252 human gut bacterial isolates, revealing that temperate gut phages are prevalent, diverse, and predominantly inactive.

A preprint by Natalia Quinones-Olvera and colleagues reports that diverse and abundant viruses exploit conjugative plasmids.

In a new preprint, Rubén Barcia-Cruz (Sorbonne Université) and colleagues describe a new family of satellites called PICMI associated with marine virulent phages.

A new preprint by Martin Plymouth, Stephanie Lynch and colleagues investigates the attitudes of Australian infectious diseases physicians towards phage therapy.

Tejas Dharmaraj (Stanford University School of Medicine) and colleagues describe the use of dynamic light scattering to measure changes in phage physical state, finding that phages tend to decay and form aggregates, and that degree of aggre

Matthias Fischer (Max Planck Institute for Medical Research) and colleagues have discovered a stunning structural diversity of giant virus-like particles in forest soil, including giant icosahedral capsids with structural modifications not

NL Haddock and colleagues published a preprint demonstrating that phage populations in infected bodily fluids mirror the abundance and diversity of bacterial pathogens, suggesting a close relationship between phages and bacteria at sites of

Denish Piya and colleagues published a preprint on genome-wide CRISPRi knockdown to map essential elements across whole phage-host genome combinations at once. Their results recapitulate the essential genes determined from decades of analys

A recent preprint by Michele Mutti and colleagues reveals that phage activity against Staphylococcus aureus is severely impaired in plasma and synovial fluid. Coagulation factors binding to the bacteria form clots that protect them from pha

In this preprint, Xin Tan and colleagues show that repeated doses of phage lead to faster phage clearance in rats and monkeys. The study found that while plasma phage titer gradually decreased over time following a single dose, repeated dos

In a new preprint, Rebekah Silva and colleagues from New England Biolabs report the first in vitro reconstitution of phage Mu's DNA hypermodification (glycine harvested from tRNA to hypermodify adenine) from purified components.

Cole Matrishin (University at Buffalo) and colleagues published a new preprint on how phages are unrecognized players in oral pathogen Porphyromonas gingivalis ecology, contributing to strain-level diversity and the species pangenome. They

In this preprint, the authors use microfluidic culture and high resolution microscopy to study how the cellular scale architecture of model 2-species biofilms impacts cell-cell and cell-phage interactions controlling larger scale population

In a new preprint, researchers from the University of Minnesota report on their efforts to catalog human gut phages using metagenome assembly and long-read sequencing.

Emily Agnello et al. present the structure of the P74-26 tail tube and introduce an in vitro system for studying the kinetics of tube assembly.

In a new preprint on bioRxiv, Eligo Bioscience researchers engineer a phage-derived particle to deliver a base editor and modify E. coli colonizing the mouse gut.