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  • Phage prohead proteases activate CBASS antiphage immunity (Science)

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  1. UpdatesFeb 24, 2024

    Hi, everyone in phage community, my name is Dr. Prince, I belong to India, and I completed my doctorate in phage characteriza

    Hi, everyone in phage community, my name is Dr. Prince, I belong to India, and I completed my doctorate in phage characterization and its application. I am looking for a postdoc position in phage biology. Please help me for the postdoc posi

    UpdatesCommunitySeeking postdocPhage biology
  2. UpdatesFeb 24, 2024

    Cytophage, a Canadian phage biotech, recently made its debut on the Toronto Stock Exchange (TSX), and just announced that the

    Cytophage, a Canadian phage biotech, recently made its debut on the Toronto Stock Exchange (TSX), and just announced that they’ve completed R&D on their OvaPhage product, to be sprayed over chicken eggs to reduce Salmonella, Escherichia, an

    UpdatesBiotech newsPublic listing
  3. UpdatesFeb 24, 2024

    BiomX got orphan drug designation from the FDA for its BX004 phage cocktail for CF P. aeruginosa. This helps lower the cost a

    BiomX got orphan drug designation from the FDA for its BX004 phage cocktail for CF P. aeruginosa. This helps lower the cost and risk of drug development through extended exclusivity, lower filing fees and access to grants.

    UpdatesOrphan DrugFDABiotech news
  4. UpdatesFeb 24, 2024

    Madison Stellfox and colleagues at the University of Pittsburgh published a new paper on phage-antibiotic combination therapy

    Madison Stellfox and colleagues at the University of Pittsburgh published a new paper on phage-antibiotic combination therapy for recurrent E. faecium. Phages were administered to a patient with increasingly severe E. faecium bloodstream in

    UpdatesPhage TherapyCase report
  5. UpdatesFeb 24, 2024

    Silvia Würstle and colleagues at the Center for Phage Biology & Therapy at Yale University published a paper on their optimiz

    Silvia Würstle and colleagues at the Center for Phage Biology & Therapy at Yale University published a paper on their optimized pipeline for emergency phage therapy against P. aeruginosa. Their pipeline includes evaluation of useful evolved

    UpdatesPhage productionPhage therapyMethods
  6. UpdatesFeb 24, 2024

    Julie Fletcher and colleagues at the University of Exeter published a paper showcasing their Citizen Phage Library's end-to-e

    Julie Fletcher and colleagues at the University of Exeter published a paper showcasing their Citizen Phage Library's end-to-end approach for rapidly isolating phages and purifying them for patient use. They’ve responded to four Phage Direct

    UpdatesPhage TherapyCitizen ScienceMethod
  7. UpdatesFeb 8, 2024

    Synthetic mRNA drives human cells to make Cpl-1 phage endolysin active against Streptococcus pneumoniae

    Researchers at University Medicine Rostock delivered synthetic mRNA encoding the Cpl-1 phage endolysin into three human cell lines (HEK293T, A549, HepG2), which produced endolysin with activity against Streptococcus pneumoniae. Adding a hum

    UpdatesPapersPhage ProteinsPhage Engineering
  8. UpdatesJan 28, 2024

    Silicon photonic-crystal nanotweezers trap and distinguish single phages without labels (Small)

    Integrated resonant photonic crystal cavities in silicon acted as optical nanotweezers that differentiated a single bacterium from a single phage without labeling or surface bioreceptors, and distinguished phages across phenotypically disti

    UpdatesPapersPhage Biology
  9. UpdatesJan 27, 2024

    M13 phage displaying amyloid-β peptides detects Aβ-oligomers in Alzheimer's brain tissue

    Researchers at the University of Minho and partner institutions show that synthetic M13 phages displaying Aβ-derived peptides bind preferentially to amyloid-β oligomers. In hippocampus tissue from APP/PS1 transgenic mice the phages detected

    UpdatesPapersPhage EngineeringDiagnostics
  10. UpdatesJan 27, 2024

    Neutrophils are not a major determinant of intravenous phage clearance in mice (bioRxiv preprint)

    In this preprint, intravenously administered antipseudomonal phage LPS-5 had blood half-lives of 3.45 and 3.66 hours in wild-type and neutropenic mice, suggesting neutrophil phagocytosis is not a major driver of phage clearance. A gap betwe

    UpdatesPapersPhage Therapy
  11. UpdatesJan 24, 2024

    First cultured deep-sea Planctomycetes strain ZRK32 releases a phage that supports nitrogen metabolism

    Researchers at the Institute of Oceanology, Chinese Academy of Sciences cultured a novel deep-sea cold-seep Planctomycetes strain, ZRK32, which they propose to name Poriferisphaera heterotrophicis. Supplementing nitrate or ammonium induced

    UpdatesPapersPhage BiologyMicrobiome
  12. UpdatesJan 5, 2024

    Review of bacteriophage-mediated strategies against polymicrobial biofilms (Frontiers in Microbiology)

    A review of in vitro attempts to use bacteriophages and their enzymes, alone or together with antibiotics and other agents, against polymicrobial biofilms, including some therapeutic uses. It also sums up the advantages, disadvantages and p

    UpdatesPapersReviewPhage Therapy
  13. UpdatesJan 3, 2024

    Vibrio cholerae CBASS antiphage system boosts killing by antifolate antibiotics

    A Nature Microbiology study from the Universities of Würzburg and Tübingen shows that in Vibrio cholerae the CBASS anti-phage signalling system increases sensitivity to antifolate antibiotics up to tenfold and enables bacterial lysis by the

    UpdatesPapersAMRPhage Biology
  14. UpdatesJan 2, 2024

    Phage Paride kills dormant, antibiotic-tolerant Pseudomonas aeruginosa by direct lytic replication

    A Nature Communications study (open access) describes Paride, a newly isolated Pseudomonas aeruginosa phage that can replicate directly in, and lyse, deep-dormant host cells, whereas other phages tested suspended replication until the host

    UpdatesPapersPhage BiologyAMR
  15. UpdatesJan 2, 2024

    Novel phage endolysin LysAB1245 is active against multiple capsular types of multidrug-resistant Acinetobacter baumannii (PLOS ONE)

    The recombinant endolysin LysAB1245, from phage T1245, showed broad activity against all clinical multidrug-resistant A. baumannii isolates tested across capsular types KL2, 3, 6, 10, 47, 49 and 52, with a reduction of more than 3 log in vi

    UpdatesPapersPhage ProteinsAMR
  16. UpdatesDec 22, 2023

    Phage Phriday on Clubhouse returns for a holiday special on Dec 22, featuring Amanda Burkardt, CEO of new therapeutic phage c

    Phage Phriday on Clubhouse returns for a holiday special on Dec 22, featuring Amanda Burkardt, CEO of new therapeutic phage company Phiogen, and Iddo Weiner, VP of research at BiomX, who recently generated some exciting new phage clinical t

    UpdatesCommunityPhage PhridayClubhouseHoliday
  17. UpdatesDec 22, 2023

    The International Bacteriophage Research Consortium (IBRC) & Open Source Pharma Foundation (OSPF) in association with the Ind

    The International Bacteriophage Research Consortium (IBRC) & Open Source Pharma Foundation (OSPF) in association with the Indian Society for Bacteriophage Research and Therapy (SBRT) have started a series of talks by clinicians with experie

    UpdatesCommunityPhage therapyWebinar
  18. UpdatesDec 22, 2023

    Did you know that VoM is heading down under? The Viruses of Microbes (VoM) Conference will take place in Cairns, Queensland,

    Did you know that VoM is heading down under? The Viruses of Microbes (VoM) Conference will take place in Cairns, Queensland, Australia, July 15-19th, 2024. Registration is open now!

    UpdatesCommunityViruses of MicrobesISVMConference
  19. UpdatesDec 22, 2023

    Cristina Leal Rodríguez (Copenhagen University Hospital) and colleagues published a new paper on how the infant gut virome is

    Cristina Leal Rodríguez (Copenhagen University Hospital) and colleagues published a new paper on how the infant gut virome is associated with preschool asthma risk independently of bacteria.

    UpdatesInfant gut phageomeAsthmaResearch paper
  20. UpdatesDec 22, 2023

    Yue Clare Lou and colleagues from the University of California, Berkeley, published a new study on the persistence of infant

    Yue Clare Lou and colleagues from the University of California, Berkeley, published a new study on the persistence of infant gut DNA phage strains during the first 3 years of life.

    UpdatesInfant gut phageomePersistenceResearch paper
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