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Aleksandra Petrovic Fabijan (Westmead Institute for Medical Research) and colleagues published a preprint on L-form switching in pathogenic Escherichia coli. They demonstrated that the osmotically fragile L-form is highly tolerant of oxidat

Michael Blazanin and Paul Turner (Yale University) published a preprint in EcoEvoRxiv on the role of community context in shaping bacteria-phage ecology and evolution. They synthesized the emerging body of bacteria-phage experiments in medi

Wai Hoe Chin (Monash University) and colleagues published a new preprint showing phage adaptation to a mammalian mucosa reveals a trans–domain evolutionary axis. Paper | Tweet thread

Ryan Cook (University of Nottingham) and colleagues published a new paper describing INfrastructure for a PHAge REference Database (INPHARED): a way to identify large-scale biases in the current collection of phage genomes. It includes a sc

Ellina Trofimova (Macquarie University, Australia) and colleagues published a new preprint describing Plaque Size Tool: an automated command-line application for plaque analysis, which can simplify and standardize phage plaque morphology me

Enea Maffei (University of Basel) and colleagues published a preprint on their systematic exploration of a new panel of 66 Escherichia coli phages, which is now available for the community. They designed the collection to be used as a refer

Elhanan Tzipilevich (Hebrew University-Hadassah Medical School) and colleagues published a new preprint showing that bacteria elicit a transient phage tolerance response subsequent to infection of their neighbors!

Jingen Zhu (The Catholic University of America, Washington, DC) and colleagues published a new preprint describing the use of CRISPR-engineered phage T4 as a universal platform to produce vaccines against SARS-CoV-2. They found high levels

Kristen LeGault (University of California, Berkeley) and colleagues published a new preprint showing how temporal shifts in antibiotic resistance elements govern virus-pathogen conflicts in Vibrio cholerae recovered from clinical samples. T

Katarzyna Danis-Wlodarczyk (Ohio State University) and colleagues published a new preprint on the antagonistic effect of colistin and ciprofloxacin on bactericidal, bacteriolytic, and virion-production activities of P. aeruginosa podovirus

Ameneh Khatami (University of Sydney) and colleagues published a new preprint showing therapeutic monitoring of the host-bacterium-phage interaction in a child. They describe how they treated a 7-year-old with a chronic osteoarticular Pseud

Some elements, termed phage-plasmids, are known to be both plasmids and phages. Eugen Pfeifer (Institut Pasteur) and colleagues screened 14,000 phages and plasmids and found 780 phage-plasmids across very diverse bacterial phyla, suggesting

There is currently no working treatment for recurring bacterial vaginosis (BV). Christine Landlinger (PhagoMed Biopharma GmbH) and colleagues published a new preprint in medRxiv showing that their engineered phage endolysin candidate elimin

Long-read genome sequencing suffers from high DNA requirements and sequencing errors, so Olivier Zablocki (Ohio State University) and colleagues developed VirION2, an integrated short- and long-read metagenomic wet-lab and informatics pipel

As there is currently no gold standard for developing a phage cocktail, Melissa Haines (University of Leicester, UK) and colleagues set out to describe a novel approach to phage cocktail development by comparing different methods side by si

Sean Benler (NCBI) and colleagues published a new preprint on their identification of thousands of previously unknown phages in whole-community human gut metagenomes.

Marion Bichet (Monash University) and colleagues published a new preprint showing that phage uptake by Eukaryotic cell layers represents a major sink for phages during therapy. Check out Marion's accompanying Twitter thread here!

Phage genomes are usually identified based on sequence similarity to genomes already in databases. Kimmo Sirén (The GLOBE Institute, University of Copenhagen) and colleagues published a new preprint showing rapid discovery of novel prophage

The phage field has seen mixed results using phages to treat oral pathogens. Sabrina Green (Baylor College of Medicine) and colleagues have uncovered new reasons behind why some phages may be particularly well-suited for gut pathogen target

Siân Owen (Harvard Medical School) and colleagues published a new preprint on a new prophage-encoded defense protein that simultaneously suppresses phage epidemics in a population (through abortive infection) and provides self-immunity to t