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Stephen Tang (Columbia University) and colleagues described de novo gene synthesis by an antiviral reverse transcriptase, showing a novel approach to gene synthesis.

Adrián Cortés-Martín (University College Cork) and colleagues published a new paper on isolation and characterization of Septuagintavirus, showing a novel clade of Escherichia coli phages within the subfamily Vequintavirinae.

Célia Souque (Harvard Medical School) and colleagues published a new paper reviewing evolutionary mechanisms driving antibiotic resistance at different scales.

Geeta Ram (NYU Grossman School of Medicine) and colleagues published a new paper on incorporating the gene encoding lysostaphin into their ‘Antibacterial Drone System’, showing expanded killing field and effective treatment of mixed bacteri

Nils Birkholz (University of Otago) and colleagues investigated the dual regulatory mechanisms of the Aca2 protein, showing that it represses anti-CRISPR gene expression by binding both DNA and RNA.

Jens Hör (Helmholtz Institute for RNA-based Infection Research, Würzburg, Germany) and colleagues at the Weizmann Institute of Science have discovered that bacteria conjugate ubiquitin-like proteins to interfere with phage assembly. Here’s

Always great to find phage researchers in countries we haven’t had representation from before! Tasnime Abdou Ahmad (American University of Beirut, Lebanon) and colleagues isolated and characterized a novel E. phage, AUBRB02. They discuss po

Emma Spencer (University of Idaho) and colleagues published a new preprint on phages of honeybee pathogen Paenibacillus larvae. They looked at resistance evolution and how phage resistant isolates developed reduced pathogenicity — and phage

Chantel Trost (University of Toronto) and colleagues found that the anti-CRISPR protein AcrIF25 disrupts the type I-F CRISPR-Cas system by pulling apart Cas7 from its guide RNA, one subunit at a time. (And it does this with no apparent enzy

Deepto Mozumdar (University of California, San Francisco) and colleagues have characterized a new lipid-based jumbo phage compartment — a hub for early phage infection. The study explores how phage ΦKZ assembles a vesicle to protect its gen

Khalimat Murtazalieva (European Bioinformatics Institute) and colleagues have discovered 145 phage anti-defence systems (ADSs) that counteract 27 of the 152 known bacterial defence families. They discuss high-throughput approaches which are

Beatriz Beamud (Institut Pasteur) and colleagues have discovered that many bacterial defense systems against phages are encoded by mobile genetic elements, challenging traditional views of bacterial immunity.

One hundred personalized phage treatments, combined! Not only did Jean-Paul Pirnay and colleagues at the Queen Astrid Military Hospital in Belgium provide phages for 100 cases, they also published a full analysis of the outcomes! This led N

Katie Wiebe (Cytophage Technologies, Inc) and colleagues have outlined a scalable and efficient production strategy for the ETEC phage ‘Phage75’, which accounts for infection load, MOI, temperature, media, harvest time, and host bacteria (t

Qingquan (Kevin) Chen (Stanford University) and colleagues have demonstrated that filamentous Pf phages of P. aeruginosa hinder antibiotic diffusion through CF sputum via electrostatic binding.

Stephen Tang (Columbia University, USA) and colleagues published a new preprint on de novo gene synthesis by an antiviral reverse transcriptase. They demonstrate bacterial creation of extrachromosomal genes via rolling-circle reverse transc

Toomas Mets (Lund University, Sweden) and colleagues published a new paper on the mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems. They show how E. coli TAC systems detect and neutralize phages by targeting m

Toshiki Nagakubo (University of Tsukuba, Japan) and colleagues published a new paper on how contractile injection systems promote Streptomyces spore formation via a phage tapemeasure-related protein.

Dimi Boeckaerts and colleagues have developed a new AI model, PhageHostLearn, which predicts Klebsiella phage-host interactions at the strain level, and in a ‘ranking format’ that is directly actionable in the lab. Paper | Behind-the-paper

Svenja Thöneböhn (Justus-Liebig-Universität Gießen, Germany) and colleagues have identified new components of the Shewanella phage LambdaSo lysis system, including a pinholin/signal-anchor-release (SAR) endolysin system and a two-component