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  1. Capsid & TailApr 4, 2025

    Tips from the lab: Rapid lab hacks

    New format alert! Here's 5 rapidfire, off-the-cuff tips from the lab — from how to tweak plaque size to purifying filamentous phages to preventing phage cross-contamination. These first 5 are written by Jessica but we hope to crowdsource th

    Phage Production and ManufacturingTechnical Aspects of Phage ResearchLab notes
  2. Capsid & TailFeb 21, 2025

    Building a phage lab: a journey of resilience, teamwork, and sticky situations

    A decade of water damage left the floors warped — and that was just the beginning. This week, Dr. Silvia Würstle shares her new lab's journey transforming an abandoned space into a cutting-edge phage lab. Setting up a new laboratory is alwa

    Personal Experiences and ReflectionsLab notes
  3. Capsid & TailSep 22, 2023

    Making our phage therapy process more efficient

    This week Jessica Sacher shares ways the Phage Australia lab team has been improving efficiency of its phage therapy system, such as dividing up work, managing expectations, overcommunicating with clinical teams, and setting up solid lab do

    Phage Therapy Access and ImplementationLab notesPhage Production and ManufacturingTechnical Aspects of Phage Research
  4. Capsid & TailJul 7, 2023

    How our phage therapy system works at Phage Australia

    At Phage Australia, we're scaling up personalized phage therapy. Jessica Sacher shares an overview of the process, to assist other centers in navigating the challenges of running a successful phage therapy (or other bio-based) service. At P

    Phage Therapy Access and ImplementationLab notesPhage Production and ManufacturingTechnical Aspects of Phage Research
  5. Capsid & TailJun 16, 2023

    Getting our AKTA-gether: Using the AKTA Flux to purify phages for patients

    This week I’m excited to share how I’ve been using the AKTA Flux system to purify phages for patients. What used to be overwhelming now feels pretty dreamy. Worth considering for any phage lab making patient-ready preps! This week I’m excit

    Phage Production and ManufacturingLab notesToolsTechnical Aspects of Phage Research
  6. Capsid & TailApr 7, 2023

    qPCR for phage therapy, part II

    This week Jessica Sacher continues her 'qPCR for phage therapy' series. She takes us through how we know if our qPCR worked, what to look for, and how to interpret how much phage/bacteria were in our samples based on the results. Welcome to

    Technical Aspects of Phage ResearchLab notes
  7. Capsid & TailMar 24, 2023

    qPCR as a window into phage therapy

    This week Jessica Sacher talks about how to use qPCR to count phage and bacteria in patients during phage therapy. This is part I of a multipart series. Lots of people have done phage therapy, but in most cases, phages and bacteria haven’t

    Technical Aspects of Phage ResearchLab notes
  8. Capsid & TailFeb 10, 2023

    Lessons in scaling bio, team science & priorities

    This week, Jessica Sacher shares learnings from setting up a pipeline for phage production/purification/QC at Phage Australia, and using it to provide phage therapy for our first 3 patients in 2022! Biggest learning: the hardest part about

    Personal Experiences and ReflectionsLab notesPhage Production and ManufacturingPhage Therapy Access and Implementation
  9. Capsid & TailSep 23, 2022

    How do we prove our phages are safe?

    Patients need safe phages, but most regulators don't yet have official positions on what makes a phage batch safe. This week, Jessica Sacher (Iredell lab, Phage Australia) shares her recent foray into learning about phage quality control an

    Regulatory and Ethical ConsiderationsLab notesTechnical Aspects of Phage ResearchPhage Production and Manufacturing
  10. Capsid & TailAug 12, 2022

    Therapeutic phage-making: how my first batch measured up

    This week Jessica Sacher shares an update on her work toward setting up a new phage-making system in the Iredell lab (part of Phage Australia). Hello everyone! Thanks so much for reading my last post, How to start making phages for therapy

    Phage Production and ManufacturingLab notesTechnical Aspects of Phage Research
  11. Capsid & TailJul 15, 2022

    How to start making phages for therapy

    This week Jessica Sacher takes us through her process for setting up a new phage-making system in the lab, including making sense of a dizzying array of options, managing overwhelm, and resisting 'optimization creep'. This article is part o

    Phage Production and ManufacturingLab notesTechnical Aspects of Phage Research

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