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  • Q&A: Favorite phage production equipment

    Issue 323Jessica Sacher

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  1. Capsid & TailAug 22, 2025

    Q&A: Favorite phage production equipment

    This week we're trying something new — let's call it Phage Community Q&A! You send us your questions, we send you off-the-cuff answers. This week, Jess shares her favorite phage-making equipment in response to a researcher who's setting up

    Phage Production and ManufacturingTechnical Aspects of Phage ResearchTools
  2. Capsid & TailAug 1, 2025

    C&T Round Up for July 2025!

    This month, we explored how Canada's first successful prosthetic joint infection phage therapy case is leading up to a full clinical trial; plus Jessica wrote a guide/manifesto(?) about why you should sequence (and re-sequence) your phages.

    Technical Aspects of Phage ResearchClinical Trials and Case StudiesPhage Production and Manufacturing
  3. Capsid & TailJul 11, 2025

    C&T Round Up for June 2025!

    This month, Jess went viral with a post about How to Read Papers, we picked some great bread and butter papers, and Jess got to chat with Cytophage about navigating the Canadian regulatory phage maze. Welcome to summer, everyone! This mont

    Regulatory and Ethical ConsiderationsPhage Production and ManufacturingTechBioTools
  4. Capsid & TailJun 13, 2025

    Our Phage Picks for June 2025

    It's Phage Picks time! This week Jess picks another 'bread-and-butter' phage lab paper about how to keep your phages stable (genetically and physically) over the decades, and Jan surfaces a killer overview of all the ways phage + AI is happ

    Phage Production and ManufacturingTechBioTechnical Aspects of Phage Research
  5. Capsid & TailJun 6, 2025

    How to navigate regulatory limbo: a Canadian phage therapy CEO's playbook

    "There's 145 components of the regulatory requirements that I don't fit in. So how do I get past that? And governments right now say, I don't know." "Phages are not drugs. Every time they say, 'Did you go through regulatory?' I say, 'I can

    Regulatory and Ethical ConsiderationsIntellectual Property and CommercializationPhage Production and Manufacturing
  6. Capsid & TailApr 25, 2025

    C&T Round Up for April 2025!

    Another round up! This month, we feature a new Lab Hacks format from Jess, one of our most controversial Capsid posts on AI use in science, and a Phage Picks of some of Jessica's nearest and dearest protocols (she uses these all the time —

    Phage Production and ManufacturingTechnical Aspects of Phage ResearchTechBio
  7. Capsid & TailApr 18, 2025

    Our Phage Picks for April 2025

    It's Phage Picks time! This week's theme is bread and butter — two picks from Jess about methods papers that should be staples of any phage lab: her favourite phage-making paper, and an (aspirational) phage quantification paper she really w

    Phage Production and ManufacturingTechnical Aspects of Phage Research
  8. Capsid & TailApr 4, 2025

    Tips from the lab: Rapid lab hacks

    New format alert! Here's 5 rapidfire, off-the-cuff tips from the lab — from how to tweak plaque size to purifying filamentous phages to preventing phage cross-contamination. These first 5 are written by Jessica but we hope to crowdsource th

    Phage Production and ManufacturingTechnical Aspects of Phage ResearchLab notes
  9. Capsid & TailMar 28, 2025

    C&T Round Up for March 2025!

    Roundup time! This month, we heard from Aaryan's experience as an undergrad researcher at Paul Bollyky's lab. We picked papers across topics like T4-AAV viral vectors, cell-free synthesis of phages, and taxMyPhage, a new tool for classifyin

    Phage Biology and ResearchPhage Production and ManufacturingIntellectual Property and Commercialization
  10. Capsid & TailMar 14, 2025

    Our Phage Picks for March 2025

    What else can phages do, besides kill bacteria? Are bacteria even needed to make them anymore? In this month's Phage Picks issue, we cover phage+AAV hybrids to deliver genes to eukaryotic cells, cell-free phage synthesis, and a bonus must-t

    Phage Therapy ApplicationsPhage Production and ManufacturingTools
  11. Capsid & TailFeb 28, 2025

    C&T Round Up for February 2025!

    Issue #300! This month we announced the return of Evergreen, covered Intralytix's 25-year-long overnight success, and Silvia's journey to build up a new phage lab. Hi phage phans, Look at that, we’re on Issue 300! That’s a really big numbe

    Intellectual Property and CommercializationPhage Community and CollaborationPhage Production and Manufacturing
  12. Capsid & TailFeb 7, 2025

    First food, then pharma: How Intralytix played the long game with phages

    "Phages? We don't use those here." This week, learn how these words propelled Sandro Sulakvelidze, fresh from phage-friendly Tbilisi, into a 25+ year journey to build a phage company with FDA-approved products. From a chance conversation ab

    Intellectual Property and CommercializationProductsPhage Production and ManufacturingRegulatory and Ethical Considerations
  13. Capsid & TailDec 20, 2024

    Year in Review 2024

    This year we moved from Sydney to San Francisco — what a year. Here's some reflections, things that went well, things that didn't, and some things we learned. Happy holidays to everyone! "Hi everyone, Thanks for making it this far — welcom

    Personal Experiences and ReflectionsPhage Production and ManufacturingTools
  14. Capsid & TailSep 27, 2024

    C&T Round Up for September 2024!

    This month we heard about how Sartorius' columns can bring down endotoxins close to zero. There's also a new phage data resource called Phage Base! Lastly, we also picked a couple of super interesting papers this month — one about how antib

    Phage Production and ManufacturingProductsTools
  15. Capsid & TailSep 20, 2024

    Using monolith chromatography to purify phages

    How do we remove impurities from our phage preparations, and get our endotoxins down close to zero? This week we've got Ažbe Žnidaršič and Lucija Rebula from Sartorius BIA Separations here to tell us about how CIMmultus monolith chromatogra

    Phage Production and ManufacturingTechnical Aspects of Phage ResearchProducts
  16. Capsid & TailJun 21, 2024

    Building a SEED library for One Health

    This week, Jonathan Moore tells us how (and why) he founded nonprofit GSD Bio to build a lactococcal phage-based vaccine production system as a public good. “Among the many lessons of COVID-19, one of the most profound is this: You don’t ne

    Phage Production and ManufacturingFunding Phage Work
  17. Capsid & TailMay 10, 2024

    Our Phage Picks for May 2024!

    Here's the third rendition of our new format: Phage Picks — where we share the papers we keep bookmarked... and keep coming back to. Hi everyone! It's Phage Picks time! This is a new monthly format we're testing out. These are casual recom

    TechBioToolsPhage Production and Manufacturing
  18. Capsid & TailApr 19, 2024

    Setting up systems to make phages available for all

    Six years ago, just as I was finishing up my microbiology PhD, I stumbled across an opportunity to help a patient. One patient turned into many, and what I used to think was 50 years away — using phages to treat infections — has become my d

    Phage Therapy Access and ImplementationPhage Production and Manufacturing
  19. Capsid & TailApr 5, 2024

    Our Phage Picks for April 2024!

    Here's the second rendition of our new format: Phage Picks — where we share the papers we keep bookmarked... and keep coming back to. Hi everyone! It's Phage Picks time! This is a new monthly format we're testing out. These are casual reco

    Technical Aspects of Phage ResearchToolsPhage Production and Manufacturing
  20. Capsid & TailMar 22, 2024

    An introduction to phage-based diagnostics

    This week, Dr. Elisabet More, Principal Scientist at PDB Biotech, shares how phages can be used as diagnostics, and how they use phages to detect M. tuberculosis hidden by the immune system. Although the use of bacteriophages for therapy is

    Phage Production and ManufacturingTechnical Aspects of Phage ResearchProducts
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