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Samuel King (Arc Institute) and colleagues published a new preprint on generative design of phage genomes using language models. Their AI model, built from Evo1 and Evo2 (millions of genomes across life), fine tuned on 15,000 Microviridae

Satheesh Nair (UK Health Security Agency) and colleagues published a new paper on genomic characterization of phage-plasmids in Enterobacteriaceae, showing these elements are present in 9% of E. coli/Shigella and 2% of Salmonella genomes, o

Naia Novy (University of Wisconsin-Madison) and colleagues published a new paper on multiobjective machine learning design of phage specificity, showing deep learning can successfully design T7 phages with precisely tuned infectivity, speci

Andrian Gajigan (University of Hawaii at Manoa) and colleagues published a new preprint on a dinoflagellate giant virus with a micron-length tail with visual similarities to a phage. They show PelV-1’s 459 kb genome encodes diverse metaboli

Toni Nagy (University of Colorado, Boulder) and colleagues published a new paper on systematic identification of phage immune triggers, showing that screening 400 phage proteins across 72 E. coli strains revealed over 100 phage-host immune

Meaghan Castledine (University of Exeter) and colleagues published a new paper on interactions between phages and macrophages, showing macrophages reduced phage efficacy and increased bacterial phage resistance, potentially explaining varia

Liana Merk (Harvard University) and colleagues published a new paper on prevalence of group II introns in phage genomes, showing group II introns are widely present in phages from diverse phylogenetic backgrounds, contrary to previous assum

Nathan Novy (University of Wisconsin-Madison) and colleagues published a new paper on multiobjective learning and design of phage specificity, showing deep learning can enhance T7 phage infectivity and specificity toward diverse bacterial s

Lukeman Kharrat (San Diego State University) and colleagues published a new paper on phage immunogenicity assessment, showing a novel Bacteriophage Risk Index to predict CpG-mediated immune activation potential of phages and guide selection

David Sünderhauf (University of Exeter) and colleagues published a new paper on CRISPR-Cas in plasmid competition, showing CRISPR-Cas benefits plasmids defensively but is limited by competitor toxin-antitoxin systems when horizontally trans

Jyot Antani (Yale University) and colleagues published a new paper on evolutionary responses of E. coli to flagellotropic phage, showing bacteria evolved resistance through flagellar mutations while retaining motility, with some strains exh

Jacopo Marchi (University of Maryland) and colleagues published a new paper on stable coexistence of phages and bacteria, showing how spatial interactions and chemotaxis enable long-term coexistence and dispersal of virulent phages with mig

Michael Shamash (McGill University) and colleagues published a new preprint on improving gut virome comparisons, showing that incorporating predicted phage host information enhances the analysis and comparison of gut viromes across differen

Amandine Maurin (University of Montpellier) and colleagues published a new paper on convergent evolution in a Salmonella phage, showing expanded host range and increased virulence evolved through parallel mutations, particularly in genes fo

Nanami Kubota (University of Pittsburgh) and colleagues published a new preprint on filamentous phage exploitation of bacteria, showing that mutant Pf phages can drive P. aeruginosa populations to lower fitness through superinfection and mi

Marian Dominguez-Mirazo (Georgia Institute of Technology) and colleagues published a new preprint on inferring phage trait heterogeneity from population data, showing latent period variation in cyanophages exceeds that of coliphages and bur

Himanshu Batra (Catholic University of America) and colleagues published a new preprint on targeted phage T4-based nanoparticles, showing these nanoparticles can reactivate latent HIV-1 in CD4+ T cells without causing global T cell activati

Arne Echterhof (Stanford University School of Medicine) and colleagues published a new preprint on modeling whole-body phage distribution in mice, using Physiologically-based Pharmacokinetic Modeling. They show rapid elimination of phage an

Amit Rimon (Hebrew University of Jerusalem) and colleagues published a new paper on comparing methods for assessing phage activity against biofilms, showing several promising techniques including calorimetry, extracellular ATP measurement,

Garyk Brixi (Arc Institute and Stanford University) and colleagues have expanded on Evo 1, which was trained on prokaryotic and phage genomes, to create Evo 2, now the largest AI model in biology. It was trained on 9.3 trillion nucleotides