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Ep 18: Discussion of Phage Therapy for CF Patients - Rebekah Dedrick

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231 news items

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  • Phage prohead proteases activate CBASS antiphage immunity (Science)

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  1. UpdatesJul 18, 2025

    Claudia Campobasso (University of Pisa) and colleagues published a new paper on serum lipid inhibition of phage activity, sho

    Claudia Campobasso (University of Pisa) and colleagues published a new paper on serum lipid inhibition of phage activity, showing human serum lipids impair Staphylococcus aureus phage infectivity in a strain-specific manner by coating bacte

    UpdatesResearch paperIn vivo phage interactions
  2. UpdatesJul 18, 2025

    Jennifer Sequoia (Stanford University) and colleagues published a new paper on phage DNA detection in umbilical cord blood, s

    Jennifer Sequoia (Stanford University) and colleagues published a new paper on phage DNA detection in umbilical cord blood, showing that phage DNA is present in human fetal circulation at birth, providing evidence of prenatal exposure to ph

    UpdatesResearch paperFetal biology
  3. UpdatesJul 18, 2025

    Jiucheng Ma (Zhangjiagang Hospital, Soochow University) and colleagues published a new paper on novel phage therapy for MDR P

    Jiucheng Ma (Zhangjiagang Hospital, Soochow University) and colleagues published a new paper on novel phage therapy for MDR Pseudomonas aeruginosa, showing vB_PaeP_PZH3 effectively reduced bacterial loads and promoted wound healing in mouse

    UpdatesResearch paperPhage therapyMouse model
  4. UpdatesJul 18, 2025

    Macrocyclic phage display identifies selective protease substrates for FAP-alpha and DPP4 (JACS)

    A phage display platform screens large libraries of chemically cyclized peptides carrying an affinity tag and a turn-on fluorescent reporter, so cleavage can be quantified in every selection round, to find selective substrates for a proteas

    UpdatesPapersPhage Engineering
  5. NewsJul 15, 2025

    NASA Crew-11 research preview includes Genes in Space-12, a student experiment on microgravity effects on bacteria and bacteriophages

    NASA's July 15, 2025 research preview for the SpaceX Crew-11 mission lists Genes in Space-12, a student-designed DNA experiment that examines the effects of microgravity on interactions between certain bacteria and bacteriophages, among inv

    NewsPhage Biology
  6. NewsJul 14, 2025

    University of Florida grants Phageolytix an exclusive worldwide license for phage cocktail technology

    The University of Florida has granted Phageolytix an exclusive worldwide license to multi-indication bacteriophage cocktails developed by researchers in its College of Medicine-Jacksonville (announced July 14, 2025). Phageolytix will manufa

    NewsIndustryManufacturing
  7. Capsid & TailJul 11, 2025

    C&T Round Up for June 2025!

    This month, Jess went viral with a post about How to Read Papers, we picked some great bread and butter papers, and Jess got to chat with Cytophage about navigating the Canadian regulatory phage maze. Welcome to summer, everyone! This mont

    Regulatory and Ethical ConsiderationsPhage Production and ManufacturingTechBioTools
  8. CommunityJul 11, 2025

    Evergreen 2025 is happening, and for the first time in its 50-year history, we're taking it on the road! Register for the 26

    Evergreen 2025 is happening, and for the first time in its 50-year history, we're taking it on the road! Register for the 26th Biennial Evergreen International Phage Meeting, which will be held August 3-8, 2025, at the University of Tennes

    CommunityConferenceEvergreen Phage Meeting
  9. UpdatesJul 11, 2025

    Why don't we have phage therapy yet? We want to understand why. Come join the fun by tuning into the Podovirus podcast! 🎙️

    Why don't we have phage therapy yet? We want to understand why. Come join the fun by tuning into the Podovirus podcast! 🎙️ Most recent episode: Dr. Marisa Azad, infectious disease physician at The Ottawa Hospital, shares her experience le

    UpdatesCommunityPodcastPodovirusPhage therapy
  10. UpdatesJul 11, 2025

    You’re invited to submit an abstract to the inaugural Conference on Bacteriophages: Biology, Dynamics, and Therapeutics, chai

    You’re invited to submit an abstract to the inaugural Conference on Bacteriophages: Biology, Dynamics, and Therapeutics, chaired by Graham Hatfull (University of Pittsburgh) and Robert (Chip) Schooley (UCSD). Topics range from phage struct

    UpdatesCommunityConferencePhage biologyPhage therapy
  11. UpdatesJul 11, 2025

    Tolka AI Therapeutics has announced expanded access to patient-tailored phage therapy for M. abscessus infections. They're sc

    Tolka AI Therapeutics has announced expanded access to patient-tailored phage therapy for M. abscessus infections. They're screening patients at five institutions for compassionate use where standard antibiotics have failed.

    UpdatesCommunityCompassionate usePhage therapy
  12. UpdatesJul 11, 2025

    Dr. Stephen Vaughan (University of Calgary) successfully treated 76-year-old Boyd English's decade-long antibiotic-resistant

    Dr. Stephen Vaughan (University of Calgary) successfully treated 76-year-old Boyd English's decade-long antibiotic-resistant hip infection using phage therapy. This is the first PJI phage treatment in Western Canada.

    UpdatesCase reportPhage therapyNews
  13. UpdatesJul 11, 2025

    Masako Shimamura (Nationwide Children's Hospital and the Ohio State University) and colleagues published a new paper on dual

    Masako Shimamura (Nationwide Children's Hospital and the Ohio State University) and colleagues published a new paper on dual β-lactam therapy for macrolide-resistant M. abscessus, showing successful treatment of two pediatric cases using mu

    UpdatesResearch paperMycobacterium
  14. UpdatesJul 11, 2025

    Kai Wang (Huazhong Agricultural University, China) and colleagues published a new paper on novel trimethoprim resistance gene

    Kai Wang (Huazhong Agricultural University, China) and colleagues published a new paper on novel trimethoprim resistance genes in phage-plasmids, showing identification of two functional dfrA genes (dfrA50 and dfrA51) that confer trimethopr

    UpdatesResearch paperPhage-plasmids
  15. UpdatesJul 11, 2025

    Jialin Xiang (Wuhan University) and colleagues published a new paper on type IV pili-mediated archaeal virus mutualism, showi

    Jialin Xiang (Wuhan University) and colleagues published a new paper on type IV pili-mediated archaeal virus mutualism, showing that co-resident temperate viruses SNJ1 and SNJ2 establish tripartite mutualistic interactions with their haloar

    UpdatesResearch paperType IV pilusTemperate phages
  16. UpdatesJul 11, 2025

    Michael Doud (University of California, San Diego) and colleagues published a new paper on AI applications in phage therapy,

    Michael Doud (University of California, San Diego) and colleagues published a new paper on AI applications in phage therapy, showing how AI can improve phage-host matching, discover novel phage genes, and guide development of synthetic ther

    UpdatesPerspectivePhage and AI
  17. NewsJul 8, 2025

    CUHK team develops phage-based nanofibre technology to enhance photodynamic cancer therapy

    A Chinese University of Hong Kong team led by Professor Mao Chuanbin built engineered bacteriophages carrying a tumour-targeting peptide, platinum nanozymes that turn hydrogen peroxide into oxygen inside tumours, and the light-activated dru

    NewsPhage Engineering
  18. NewsJul 8, 2025

    Bacteriophage Symphony: engineering phages as live biocomputers to reprogram microbial communities

    Harvard Undergraduate Microbiology Society article by Ishaan Vitthala on “programmable” phages that deliver genetic circuits to reprogram bacteria rather than only kill them, with possible uses in the gut microbiome, agriculture, wastewater

    NewsPhage Engineering
  19. UpdatesJul 6, 2025

    Genomic characterization of four Salmonella-specific bacteriophages and evaluation of their cocktail efficacy in milk (Food Science and Biotechnology)

    Jung and colleagues analysed the genomic, proteomic and functional characteristics of four bacteriophages (STP-1 to STP-4) targeting Salmonella Typhimurium, finding lysis-related genes (holin, endolysin, RZ-like spanins) and no genes linked

    UpdatesPapersFood SafetyPhage Genomics
  20. UpdatesJul 1, 2025

    BX004-A first-in-human trial

    A first-in-human, double-blind, placebo-controlled phase 1b/2a trial evaluated nebulized three-phage cocktail BX004-A in nine adults with cystic fibrosis and chronic Pseudomonas aeruginosa infection. The trial met its primary safety and tol

    UpdatesPapers
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