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Parallel sequential fluorescence in situ hybridization (par-seqFISH) profiled the transcriptional activity of individual phage lambda genomes during synchronized infection of E. coli. Cells pursuing lysogeny show consensus activity among al

Meijer, Skiadas, Rainey, Hogeweg and Dutilh tracked viral dynamics in 20 compost-derived microbial communities over one year and observed massive, parallel outbreaks of Theomophage, a previously uncharacterized member of the Schitoviridae t

Metagenomics, metatranscriptomics and metabolic modelling followed a thermophilic CO2-converting (biomethanation) trickle bed reactor over 353 days of stepwise gas-feed perturbations, tracking single nucleotide variant trajectories in both

Science news feature by Richard Stone (Science 392, issue 6800, May 21, 2026, pp. 800-804), whose standfirst states that key human defenses against pathogens were forged billions of years ago in microbial battles with viruses. Science — "Br

Biochemistry, cryo-electron microscopy and single-molecule imaging show that Hna, a broadly distributed anti-phage system that triggers abortive infection, is a 3'-5' single-stranded DNA exonuclease forming an auto-inhibited dimer under phy

A structural and functional study of QatB and QatC, two components of the four-protein QatABCD anti-phage defense system. QatC bound to the ATP analog AMPPNP and the QatB-QatC heterodimer were solved, and structural analysis suggests QatB m

More than two-thirds of Streptococcus thermophilus strains harbor a phage satellite structurally similar to Staphylococcus aureus pathogenicity islands (SaPIs). Virulent phages can trigger induction of these satellites, and their DNA can th

Lytic Selection and Evolution (LySE) uses a modified bacteriophage to evolve long gene clusters. In a proof of concept, the team improved bacterial degradation of a plastic ingredient by more than 50% after five cycles. National University

A high-throughput droplet microfluidics platform co-encapsulates individual phages and bacteria to quantify single phage infection events, with control over exposure time and the phage-to-bacteria ratio. It measures lysis events and lysis k

Large-scale comparative cell biology and biochemistry of 16 bacterial nuclease-NTPase antiphage defence systems shows that protein-protein complex formation is a shared feature. The nucleases of the Pa AbpAB, Bt Hachiman and Ec PD-T4-8 syst

A perspective arguing that traditional bacteriophage methods measure population averages and miss variation between individual particles. It advocates optical microscopy and flow cytometry approaches that can reveal phenotypic heterogeneity

McMaster University researchers report in mBio (published March 30, 2026) that Pseudomonas aeruginosa can evade phage attack by entering a temporary "stealth mode". Of 28 phage-resistant mutants studied, one regained full pili function in a

Godsil, Wei and Meeske report in Nature Microbiology that the Listeria seeligeri type VI-A CRISPR system restricts the lytic cycle of temperate phages but tolerates prophage acquisition and interferes with prophage induction through a non-a

Damgaard and colleagues report in Communications Medicine that Bacteroides fragilis isolates from colorectal cancer (CRC) patients are infected with specific Caudoviricetes prophages significantly more often than controls, a finding made by

Patel and colleagues describe in Nature a 164-residue prophage-encoded defence protein, ring interacting pore 1 (Rip1), that is activated by the portal or small terminase proteins of infecting phages, oligomeric ring-shaped complexes essent

A team led by the Singapore-MIT Alliance for Research and Technology (SMART) AMR group, with MIT, the University of Otago and other partners, reports in Cell Host & Microbe a new type of phage DNA modification: arabinose added to cytosine a

A PLOS Biology study by Huss, Chitboonthavisuk, Meger and colleagues reports the dynamics between T7 bacteriophage and Escherichia coli aboard the International Space Station: phage activity was initially delayed in microgravity but ultimat

Lund University advertised a one-year full-time bioinformatician role to classify bacterial antiphage defenses, maintain web portals and work with experimental teams. The listing gives a January 26, 2026 deadline and states that application

Dr Piotr Golec of the Department of Molecular Virology, Institute of Microbiology, Faculty of Biology UW has received PLN 1,881,850 from the National Science Centre (NCN) under its OPUS 29 call for a project on interactions between lytic ph

Silverman and colleagues used RIL-seq to map RNA–RNA interactions in Escherichia coli during phage lambda infection, reported in Molecular Cell, and identified a phage-encoded small RNA, PreS (phage replication enhancer sRNA), embedded in t