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Xiang Hou (Jiangsu Academy of Agricultural Sciences, China) and colleagues published a new paper on a repressor, RptR, that controls Type I restriction modification system defence islands. They show that RptR binds TAGCTA repeats to silence

Iddo Weiner (BiomX Ltd) and colleagues published a new paper on their nebulized phage cocktail for cystic fibrosis, showing BX004-A met safety endpoints and demonstrated potential reduction in P. aeruginosa sputum burden in first-in-human t

Claudia Campobasso (University of Pisa) and colleagues published a new paper on serum lipid inhibition of phage activity, showing human serum lipids impair Staphylococcus aureus phage infectivity in a strain-specific manner by coating bacte

Jennifer Sequoia (Stanford University) and colleagues published a new paper on phage DNA detection in umbilical cord blood, showing that phage DNA is present in human fetal circulation at birth, providing evidence of prenatal exposure to ph

Jiucheng Ma (Zhangjiagang Hospital, Soochow University) and colleagues published a new paper on novel phage therapy for MDR Pseudomonas aeruginosa, showing vB_PaeP_PZH3 effectively reduced bacterial loads and promoted wound healing in mouse

Masako Shimamura (Nationwide Children's Hospital and the Ohio State University) and colleagues published a new paper on dual β-lactam therapy for macrolide-resistant M. abscessus, showing successful treatment of two pediatric cases using mu

Kai Wang (Huazhong Agricultural University, China) and colleagues published a new paper on novel trimethoprim resistance genes in phage-plasmids, showing identification of two functional dfrA genes (dfrA50 and dfrA51) that confer trimethopr

Jialin Xiang (Wuhan University) and colleagues published a new paper on type IV pili-mediated archaeal virus mutualism, showing that co-resident temperate viruses SNJ1 and SNJ2 establish tripartite mutualistic interactions with their haloar

Victoria Harman-McKenna (University of Calgary) and colleagues published a new paper on intestinal protection using mycobacteriophages, showing that lining the small intestine with phages protects against Mycobacterium avium subsp. paratube

Geunsoo Jung, Hyunwoo Zin (Sejong University, Korea) and colleagues published a new paper on characterization of a plasmid-dependent DNA phage, showing it selectively targets E. coli harboring conjugative plasmids and reduces their abundanc

Katrina Black (Walter and Eliza Hall Institute of Medical Research, Australia) and colleagues published a new paper on resolving a T1-like bacteriophage outbreak, showing how targeted deletion of an LptD loop conferred resistance to the pha

Vida Štilec (University of Ljubljana) and colleagues published a new paper on high quality preparation and pharmacokinetics of S. epidermidis phage COP-80B in a mouse model. They saw that injection into the joint provided local phage presen

Taylor Andrews (Rutgers University) and colleagues published a new paper on re-expansion of host range in RNA phage phi6, showing specialized phi6 strains readily regained broader host ranges through both reversion and compensatory mutation

Ortal Yerushalmy (Hebrew University of Jerusalem) and colleagues published a new paper on phage susceptibility diversity in CF Burkholderia isolates, showing mixed populations of phage-sensitive and phage-resistant Burkholderia in 75% of CF

Cristian Crisan (Emory University) and colleagues published a new paper on phages lysing cystic fibrosis S. maltophilia isolates, describing isolation both specialist and generalist phages that infect diverse S. maltophilia strains.

Atif Khan and Hiren Joshi (Bhabha Atomic Research Centre, India) published a new research paper on selectively enriching and characterizing stress-tolerant phages for food biocontrol.

Eleanor Rand (Harvard Medical School) and colleagues published a new paper on a targeted phage discovery method called Phage DisCo, a co-culture-based phage screening technique. Using isogenic, fluorescently tagged bacterial strains, they c

Stephen Tang (Columbia University) and colleagues published a new paper on protein-primed homopolymer synthesis, showing a novel bacterial antiviral defense mechanism involving synthesis of poly-dA DNA triggered by phage infection, driven b

Tianjing She (Nanjing Agricultural University) and colleagues published a new paper on phage-mediated gene transfer in Salmonella, showing horizontal transfer of virulence genes in Salmonella enterica with regulatory feedback from the host.

There’s a lot of improvement we can engineer into phages! Phil Huss (University of Wisconsin-Madison) and colleagues published a new paper on engineering phages using metagenomic data, showing how deep mining of metagenomic motifs can be us