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Michael Schelling et al. published a new paper in PLOS Biology on how CRISPR-Cas effector specificity and cleavage site determine phage escape outcomes. They find that most pre-existing crRNA mismatches lead to phage escape, regardless of w

iPHoP, from the DOE Joint Genome Institute, is a two-step framework that integrates multiple methods to predict host taxonomy at the genus rank for viruses infecting bacteria and archaea while retaining a low false discovery rate. Applied t

From Timofey Skvortsov via Twitter: Hi all, where are you sequencing your new phage/bacterial isolates in the UK/Ireland these days? I'd appreciate any suggestions or insights!

In celebration of International Women's History Month, this episode of the Phage Files podcast looks back at female phage researchers' contributions to early phage research. The hosts interview Dr. Elizabeth Kutter (Evergreen State College)

In this episode of Breakpoints podcast, Dr. Saima Aslam and Dr. Daria Van Tyne join Dr. Rachel Britt for a discussion on phage therapy! Tune in for a review of their role in therapy, logistical considerations, the future of phage therapy, a

A European public consultation on a new general chapter in the European Pharmacopeia on phage therapy active substances and medicinal products of human and veterinary use is open (until end of June). This is a unique opportunity to help sha

IPATH's Translational Research in Bacteriophage Therapies Seminar Series has returned this year, featuring three speakers: Daria Van Tyne, Joseph Bondy-Denomy, and Austen Terwilliger. Watch recordings of them on YouTube, and catch upcoming

In this episode of Phage Therapy Today podcast, Dr. Gina Suh shares her recent progress and experience in applying phage therapy at Mayo Clinic.

Check out the Special Issue "The Phage: Biology and Therapeutic Use," published by Microorganisms and edited by Richard James (University of Nottingham) and David R. Harper (Evolution Biotechnologies). The deadline for manuscript submission

The Oxford Phage Meeting (Sept 4th-5th) is happening this year.

The Molecular Genetics of Bacteria and Phages Meeting in Madison, Wisconsin (Aug 7th-11th) is happening this year.

When the CDC reported a recent outbreak of extensively drug-resistant (XDR) Pseudomonas aeruginosa linked to artificial tears, IPATH's Co-Director, Chip Schooley, requested the Pseudomonas isolates associated with the outbreak. Fortunately,

Yunha Hwang and colleagues found that virus-host interactions in dense hydrothermal mats involve crossing microbial domains and nested metabolisms. They saw that unrelated microbes encode CRISPR immunity against the same viruses, suggesting

Nikhil George & Laura Hug examined a landfill via virus-host CRISPR spacer mapping, and found multiple examples of atypical virus-host dynamics, such as hyper-targeted viral populations, interviral conflicts, and non-specific viruses.

Tram Le and colleagues show the therapeutic potential of IV phage for recurrent urinary tract infections, describing a kidney transplant recipient with ESBL Klebsiella pneumoniae who was successfully treated with 4 weeks of IV phage therapy

Olaya Rendueles and colleagues have described how fitness costs drive competition between lysogenic and sensitive bacteria by co-cultivating a phage-sensitive strain and a polylysogenic Klebsiella pneumoniae strain under different phage pre

Top Agar Question This is a basic question but one I do need advice with. My high school phage team will begin looking for a phage next fall from a new host. The host has not been studied much for phages. How do you choose a top agar for n

Phages seem to be saving lives left and right, but still, they remain unapproved drugs in most countries. Pharma companies don't sell them; hospitals and pharmacies don’t stock them. In this Wired article, Maryn McKenna covers phage therapy

In a new paper in Nature, Joseph Kreitz (Howard Hughes Medical Institute) and colleagues show that Photorhabdus virulence cassette (PVCs), part of a class of syringe-like nanomachines resembling phage tails, can be reprogrammed for protein

By analyzing metagenomic samples from IBD patients, Shaqed Carasso (Technion-Israel Institute of Technology) and colleagues identified invertible regions that correlate with disease, including Bacteroides fragilis polysaccharide-A, which is