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Ep 18: Discussion of Phage Therapy for CF Patients - Rebekah Dedrick

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  1. UpdatesJan 14, 2022

    Preprint: Class I DISARM provides anti-phage and anti-conjugation activity by unmethylated DNA recognition.

    Preprint: Class I DISARM provides anti-phage and anti-conjugation activity by unmethylated DNA recognition.

    UpdatesPhage defense systemsPreprint
  2. UpdatesJan 14, 2022

    Preprint: a novel locally c-di-GMP-controlled exopolysaccharide synthase is required for phage N4 Infection of E. coli.

    Preprint: a novel locally c-di-GMP-controlled exopolysaccharide synthase is required for phage N4 Infection of E. coli.

    UpdatesPhage-host interactionsPreprint
  3. UpdatesNov 26, 2021

    Cell wall deficiency may limit the efficacy of phage therapy.

    Cell wall deficiency may limit the efficacy of phage therapy.

    UpdatesPhage resistancePhage-host interactionsPreprint
  4. UpdatesNov 26, 2021

    A temperate phage model system reveals new strains, species, prophage integration loci, conserved proteins and lysogeny manag

    A temperate phage model system reveals new strains, species, prophage integration loci, conserved proteins and lysogeny management components.

    UpdatesPreprintProphageResearch paper
  5. UpdatesNov 5, 2021

    Conventional homology-based comparative genomic analyses can only do so much in extracting information from databases. We use

    Conventional homology-based comparative genomic analyses can only do so much in extracting information from databases. We used phages to test our comparative genomics tool (CALANGO) that considers annotation terms besides sequence data. By

    UpdatesCommunityBioinformatics ToolPreprint
  6. UpdatesOct 8, 2021

    Michael Shamash (McGill University) and Corinne Maurice published a new pre-print on bioRxiv on the app they developed called

    Michael Shamash (McGill University) and Corinne Maurice published a new pre-print on bioRxiv on the app they developed called OnePetri: accelerating common bacteriophage Petri dish assays with computer vision. Check out the behind the app a

    UpdatesPhage AppsPreprint
  7. UpdatesOct 1, 2021

    Shiraz Shah (Copenhagen University Hospital, Denmark) and colleagues published a new paper in bioRxiv showing hundreds of vir

    Shiraz Shah (Copenhagen University Hospital, Denmark) and colleagues published a new paper in bioRxiv showing hundreds of viral families in the healthy infant gut. These results were obtained from sequencing and analysing fecal viromes from

    UpdatesGut viromePreprint
  8. UpdatesSep 24, 2021

    Anshul Sinha (McGill University, Canada) and colleagues published a pre-print showing that the transplantation of phages from

    Anshul Sinha (McGill University, Canada) and colleagues published a pre-print showing that the transplantation of phages from ulcerative colitis patients shifts the gut bacteriome and exacerbates severity of induced colitis.

    UpdatesGut microbiomePreprint
  9. UpdatesSep 17, 2021

    Andrzej Zielezinski (Adam Mickiewicz University, Poland) and colleagues published a new preprint describing PHIST, a fast and

    Andrzej Zielezinski (Adam Mickiewicz University, Poland) and colleagues published a new preprint describing PHIST, a fast and accurate prediction of prokaryotic hosts from metagenomic viral sequences.

    UpdatesBioinformatics ToolHost predictionMetagenomicsPreprint
  10. UpdatesAug 20, 2021

    Sooyeon Song (Pennsylvania State Universtiy, Pennsylvania) and colleagues published a preprint on how CRISPR-Cas controls cry

    Sooyeon Song (Pennsylvania State Universtiy, Pennsylvania) and colleagues published a preprint on how CRISPR-Cas controls cryptic prophages. They demonstrated that the E. coli CRISPR-Cas system is active and inhibits its nine defective prop

    UpdatesCRISPRCryptic prophagesPreprint
  11. UpdatesAug 20, 2021

    Xiaoqing Wang (Zhejiang University-University of Edinburgh Institute, China) and colleagues published a new preprint on how p

    Xiaoqing Wang (Zhejiang University-University of Edinburgh Institute, China) and colleagues published a new preprint on how phage resistance mechanisms increase colistin sensitivity in Acinetobacter baumannii.

    UpdatesAMRPhage resistancePreprintResearch paper
  12. UpdatesAug 13, 2021

    Christopher Turkington (University of California, Merced) and colleagues published a preprint on hafeZ, a tool able to identi

    Christopher Turkington (University of California, Merced) and colleagues published a preprint on hafeZ, a tool able to identify ‘active’ prophages within bacterial genomes through genomic read mapping. They've applied hafeZ to publicly avai

    UpdatesBioinformatics ToolComputational biologyPreprintProphage identification
  13. UpdatesAug 13, 2021

    Quentin Leclerc (London School of Hygiene & Tropical Medicine) and colleagues published a preprint on the dual nature of phag

    Quentin Leclerc (London School of Hygiene & Tropical Medicine) and colleagues published a preprint on the dual nature of phage: growth-dependent predation and generalized transduction of antimicrobial resistance. They developed mathematical

    UpdatesMathematical biologyPhage-bacteria dynamicsPreprint
  14. UpdatesAug 6, 2021

    Jonathan Lynch (University of Hawaii, USA) and colleagues published a preprint on host- and bacterium-based determinants that

    Jonathan Lynch (University of Hawaii, USA) and colleagues published a preprint on host- and bacterium-based determinants that protect squid-associated Vibrio fischeri from phage predation. They show that mutations in V. fischeri's exopolysa

    UpdatesPhage predationPreprint
  15. UpdatesAug 6, 2021

    Rosanna Wright (University of Manchester, UK) and colleagues published a preprint on how functional diversity increases effic

    Rosanna Wright (University of Manchester, UK) and colleagues published a preprint on how functional diversity increases efficacy of phage combinations. Their findings suggest that functional diversity is the key to effective phage combinati

    UpdatesPhage TherapyPhage diversityPreprint
  16. UpdatesJul 30, 2021

    Yue Liu (Wageningen University & Research, Netherlands) and colleagues published a new preprint investigating a phenomenon wh

    Yue Liu (Wageningen University & Research, Netherlands) and colleagues published a new preprint investigating a phenomenon where massive numbers of lipid-engulfed tailless phage particles are released from Lactococcus lactis without causing

    UpdatesNon-lytic phage releasePreprintResearch paperTailless phage
  17. UpdatesJul 23, 2021

    Luke Hillary (Bangor University, UK) and colleagues published a preprint on how diverse soil RNA viral communities have the p

    Luke Hillary (Bangor University, UK) and colleagues published a preprint on how diverse soil RNA viral communities have the potential to influence grassland ecosystems across multiple trophic levels. They ide

    UpdatesPreprintSoil viruses
  18. UpdatesJul 16, 2021

    Hayley Nordstrom (University of Pittsburgh School of Medicine) and colleagues published a preprint showing genomic and functi

    Hayley Nordstrom (University of Pittsburgh School of Medicine) and colleagues published a preprint showing genomic and functional characterization of P. aeruginosa-targeting phages isolated from hospital wastewater. They used a panel of cli

    UpdatesPhage characterizationPhage genomicsPreprint
  19. UpdatesJul 9, 2021

    Nichith Ratheesh (Arizona State University) published a preprint on how a member of the oral microbiota can actively transpor

    Nichith Ratheesh (Arizona State University) published a preprint on how a member of the oral microbiota can actively transport phages by swarming, leading to disruption of E. coli biofilms. They found that Capnocytophaga gingivalis forms tu

    UpdatesOral microbiotaPreprintResearch paperSwarming
  20. UpdatesJul 2, 2021

    Tamsin Redgwell (Copenhagen University Hospital) and colleagues published a preprint in bioRxiv describing how prophages in t

    Tamsin Redgwell (Copenhagen University Hospital) and colleagues published a preprint in bioRxiv describing how prophages in the infant gut are largely induced, and may be functionally relevant to their hosts. They found prophages in the inf

    UpdatesGut phageomePreprintProphage
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