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Elizabeth Burgener (Children's Hospital of Los Angeles) and colleagues published a new paper on how Pf phage impacts cystic fibrosis patients, with Pseudomonas infections, showing high Pf in sputum is associated with lung function decline a

Jyot Antani (Yale University) and colleagues developed a microscopy-based technique to measure phage attachment to bacterial cells. This method provides an attractive alternative to the (literally) century-old Phage Adsorption Assay because

Tong Zhang (Massachusetts Institute of Technology) and colleagues discovered a bacterial immunity protein that senses two unrelated phage proteins, showing that CapRelSJ46 in E. coli can directly bind two structurally different phage protei

Peter Erdmann Dougherty (University of Copenhagen) and colleagues isolated and sequenced 8 novel phages targeting wheat phyllosphere bacteria, characterizing their genomic, phylogenetic, and morphological traits. They identified DNA modific

Mihály Koncz (HUN-REN Biological Research Centre, Szeged, Hungary) and colleagues combined phylogeographic analysis with phage typing to guide precision phage therapy, showing that a few carbapenem-resistant A. baumannii strain types domina

Yunxue Guo (Chinese Academy of Sciences) and colleagues discovered a reverse transcriptase-mediated mechanism of prophage genome reduction in P. aeruginosa biofilms, showing that Pf4 phage-encoded RT and an ncRNA collaborate to generate sup

Tetrapyrroles such as heme, chlorophyll, and vitamin B12 are essential for various metabolic pathways. Helen Wegner (University of Kaiserslautern-Landau, Germany) and colleagues demonstrated the presence of tetrapyrrole genes in phage seque

Stephano Iglesias (Thomas Jefferson University, Philadelphia) and colleagues created a high-resolution structural atlas of Pseudomonas phage Pa193 using bioinformatics, proteomics, and cryogenic electron microscopy single particle analysis.

David Mayo-Muñoz (University of Otago, New Zealand) and colleagues identified noncoding RNAs as key players in bacteria–phage conflicts, showing their roles in bacterial immunity and anti-defense mechanisms.

Peiying Ho and colleagues from the Singapore-MIT Alliance for Research and Technology screened the PA14NR transposon mutant library and identified key genes involved in P. aeruginosa phage resistance. They found 78 mutants capable of thrivi

A novel phage, TS33, targeting Hafnia species in a model Brie-like cheese community; many host factors that contribute to infectivity are O-antigen genes.

The BASEL collection of E. coli phages has been expanded — 36 new ones have been added! These phages were deeply characterized genomically and phenotypically, from receptors to antiviral defense sensitivity to host range. Looking at the res

A phage cocktail targeting Yersinia pestis provided ~88% post-exposure protection in a rat model of pneumonic plague!

Here’s a handy comparison of expression systems for phage lysin production, with key considerations for host selection and evaluating recent literature.

A new first in human phase 1 randomized, double-blind trial of Intralytix's ShigActive™, a Shigella phage preparation, shows it is safe and well tolerated when orally administered.

Guadalupe Valencia-Toxqui and Jolene Ramsey (Texas A&M University) published a new phage classification guide, orienting newcomers to four common ways phages are currently classified: infection cycle, morphology, taxonomy, and supergroup. B

Nicolas Kieffer (Universidad Complutense de Madrid) and colleagues published a new preprint on identification of phage defense systems encoded by mobile integrons, showing that integrons can encode phage defense systems, including Lamassu,

Max Wilkinson (Massachusetts Institute of Technology) and colleagues have described how phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA, showing a new mode of genetic regulation in prokaryotes.

Amit Rimon (Hebrew University of Jerusalem) and colleagues published a new paper on combinatorial treatment of pulsed blue light and phage therapy for antibiotic-resistant P. aeruginosa, showing a synergistic bactericidal effect on plankton

Paul Kim (Locus Biosciences, Inc.) and colleagues published a paper on the results of the first phase of their Phase 2 ELIMINATE clinical trial, where they used a CRISPR-Cas3-enhanced phage cocktail to treat uncomplicated urinary tract infe