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Tulane Ventures has invested $250,000 in Biophoundry, a Tulane University spinout developing engineered phage therapies for antibiotic-resistant infections. Its Phax platform couples computational phage design and selection with rapid phage

Competition-funded PhD project in the School of Biochemistry and Biomedical Sciences, University of Bristol (Dr Maisem Laabei, Dr Scott Lovell), through the GW4 BioMed3 MRC DTP. It uses a covalent phage display platform from the Lovell lab

Phage Tn-seq is a transposon-based approach to studying phage gene essentiality and engineering. Nature Microbiology

University of Wisconsin–Madison biochemists led by Vatsan Raman built an AI model that identifies phage mutations with the greatest potential to improve targeting and killing of bacteria. In laboratory tests, phages carrying AI-suggested mu

The first patient has been enrolled in Part 2 of the Phase 1b/2a clinical trial of SNIPR001, an investigational CRISPR-armed phage therapeutic candidate for preventing E. coli bloodstream infections in hematopoietic stem cell transplant pat

Stanford researchers led by Brian Hie and Samuel King used Evo 2, a generative AI model that writes whole genomes, to design novel bacteriophage genomes starting from ΦX174. They synthesized nearly 300 phages, tested them against E. coli an

Using the Klebsiella podophages KP32, K11 and KP34, the authors validated the interaction between the primary RBP branching domain and the secondary RBP docking peptide. They used this interaction to engineer a KP32 scaffold that propagated

Lytic selection and evolution (LySE) is a T7-based method for near-continuous directed evolution of bacterial gene clusters that keeps discrete checkpoints: a hypermutagenic T7 DNA polymerase mutates a target gene cluster carried on a T7 ph

Sikkema and colleagues describe in PNAS an engineering platform for the phiKMV-like Pseudomonas aeruginosa phage 41S1 built on one-pot High Complexity Golden Gate assembly (HC-GGA): the genome is divided into synthesizable DNA fragments tha

Silver nanoparticles templated by the Escherichia coli phage M13 showed unusually high potency against Gram-negative pathogens including E. coli, Pseudomonas aeruginosa and Vibrio cholerae in vitro, and elicited resistance more than 10-fold

Biofilm-adapted mutants of Pseudomonas phage PE1, evolved on a cystic fibrosis-derived P. aeruginosa isolate, controlled biofilms better in vitro under conditions mimicking the CF lung. Mutations in tail fiber and baseplate genes improved a

Bacteriophage T4 capsid nanoparticles arrayed with a CD4-binding DARPin or the HIV-1 gp140 envelope trimer reactivated HIV-1 latency in J-Lat T cell models and primary T lymphocytes without global T cell activation or cytokine storm, indepe

I’m Harshu (Biophysics MD-PhD @ Shipman Lab, UCSF) – looking for an undergraduate (anyone from bioengineering, biochemistry, MCB, computational bio, microbiology is welcome) to start sometime in September 2025. Project description: re-engi

Naia Novy (University of Wisconsin-Madison) and colleagues published a new paper on multiobjective machine learning design of phage specificity, showing deep learning can successfully design T7 phages with precisely tuned infectivity, speci

University of Waterloo School of Pharmacy researchers use a modified version of the M13 bacteriophage to deliver chosen therapeutic genes to specific human cells, with no unwanted virus or bacteria, as a cheaper and more efficient route to

iNtRON Biotechnology announced on August 5, 2025 that its IMPA (Intelligent Modular Phage Assembly) phage engineering technology produced a phage carrying a colibactin-degrading protein on its capsid. The company says the engineered phage k

A phage display platform screens large libraries of chemically cyclized peptides carrying an affinity tag and a turn-on fluorescent reporter, so cleavage can be quantified in every selection round, to find selective substrates for a proteas

A Chinese University of Hong Kong team led by Professor Mao Chuanbin built engineered bacteriophages carrying a tumour-targeting peptide, platinum nanozymes that turn hydrogen peroxide into oxygen inside tumours, and the light-activated dru

Harvard Undergraduate Microbiology Society article by Ishaan Vitthala on “programmable” phages that deliver genetic circuits to reprogram bacteria rather than only kill them, with possible uses in the gut microbiome, agriculture, wastewater

SNIPR Biome in Copenhagen is hiring a Research Assistant in Phage Engineering. The work will include basic phage science involving steps from isolation to thorough characterization of genome and phenotype, including comprehensive host range