Search

Hannah Kapoor (Oregon State University) and colleagues published a new paper on phage-mediated TLR2 signaling against intracellular Mycobacterium abscessus, showing certain mycobacteriophages stimulate TLR2 signaling and NLRP3 inflammasome

Sophia Zborowsky (Institut Pasteur) and colleagues published a new paper on macrophage interference with phage therapy efficacy, showing alveolar macrophages reduce phage density through phagocytosis and adsorption inhibition, limiting ther

Toni Nagy (University of Colorado, Boulder) and colleagues published a new paper on systematic identification of phage immune triggers, showing that screening 400 phage proteins across 72 E. coli strains revealed over 100 phage-host immune

Xiang Hou (Shanghai Jiao Tong University School of Medicine) and colleagues published a new paper on gut phage-induced macrophage reprogramming, showing phages epigenetically prime macrophages via IL-10 to generate LPS-tolerant innate memor

Meaghan Castledine (University of Exeter) and colleagues published a new paper on interactions between phages and macrophages, showing macrophages reduced phage efficacy and increased bacterial phage resistance, potentially explaining varia

Fernando Gordillo Altamirano (Monash University) and colleagues published a new paper on phage therapy failure mechanisms, showing pre-existing anti-prophage antibodies and bacterial heteroresistance contributed to treatment failure in a pa

This Week in Virology (TWiV) recorded a special live podcast episode at the 2024 Viruses of Microbes meeting in Cairns, Australia. Hosts Vincent Racaniello and Jolene Ramsey interviewed phage researchers Krystyna Dabrowska and Rob Lavigne a

This Week in Virology (TWiV) recorded a special live podcast episode at the 2024 Viruses of Microbes meeting in Cairns, Australia. Hosts Vincent Racaniello and Jolene Ramsey interviewed phage researchers Krystyna Dabrowska and Rob Lavigne a

David Harper discusses the complexities and limitations of using phages as therapeutics in his recent LinkedIn post, emphasizing the challenges posed by the immune system and the size of phages compared to conventional antibiotics.

Associate Professor Jeremy Barr (Monash University) received $500,000 USD from the Bill & Melinda Gates Foundation to investigate how phages interact with the human immune system and their potential implications for treating inflammatory di

In a recent podcast episode of This Week in Virology (TWiV), learn how a viral capsid protein activates a bacterial innate immune system, interfering with protein synthesis, and human-associated redondoviruses that infect the commensal prot

University of Exeter is hiring a PhD researcher to employ high-resolution cryoEM imaging to achieve atomic-level structural characterisation of Burkholderia phages and study their adaptations to evade clearance by the innate immune system i

A recent preprint by Michele Mutti and colleagues reveals that phage activity against Staphylococcus aureus is severely impaired in plasma and synovial fluid. Coagulation factors binding to the bacteria form clots that protect them from pha

In a new preprint, Medeea Popescu and colleagues report that the bacteriophage Pf4, produced by Pseudomonas aeruginosa, dampens inflammatory responses in response to either P. aeruginosa airway infection in a mouse model of acute pneumonia

Paper: Immunological and safety profile of bacteriophages therapy: a preclinical study.

Paper: Increased innate immune susceptibility in hyperpigmented phage-resistant mutants of P. aeruginosa.

Pre-print: An expanding arsenal of immune systems that protect bacteria from phages.

Pre-print: RNA-targeting CRISPR-Cas13 provides broad-spectrum phage immunity

Snapshot: Bacterial immunity in response to phage infection

Postdoctoral position to work on bacterial immune response to phage at Washington University, St. Louis