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In this issue of Cell, Brianna Duncan-Lowey et al. and Yina Gao et al. both show RADAR proteins assemble into massive molecular complexes but present distinct views about how these assemblies obstruct phage.

A new Transplant Infectious Diseases study by Ghady Haidar (University of Pittsburgh School of Medicine) and colleagues reports the use of nebulized phage therapy to treat Burkholderia multivorans in a CF patient. Unfortunately this was a c

Amit Rimon (Hebrew University of Jerusalem) and colleagues published a new paper in Nature Communications on topical phage therapy in a mouse model of Cutibacterium acnes-induced lesions. They found that phage therapy may be a promising str

Cyanophages play an important role in controlling the abundance of their hosts, which are globally significant populations of Prochlorococcus and Synechococcus. In a new paper published in Viruses, Emily Dart (Clark University) and colleaug

In this study, Benjamin A. Adler (University of California, Berkeley) and colleagues used a high-throughput genetic screen to uncover genome-wide host suppressors of diverse single-gene lysis proteins (Sgls). See also this interview with th

A new paper in Nature Microbiology by Madison C. Williams (University of Washington) and colleagues entitled Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy reports that restriction

In a new preprint, Enea Maffei (University of Basel) and colleagues describe a new phage, Paride, which is able to kill dormant, antibiotic-tolerant bacteria. They suggest that this phage hijacks weak spots in the dormant physiology of anti

In a new paper in Viruses, Sandrine Le Guellec and colleagues describe a preclinical study involving macaques to predict the efficacy of delivery of nebulizer-administered Pseudomonas aeruginosa phages during mechanical ventilation. They fo

In a new paper in Food Microbiology, Marta Volpi and colleagues report on a full-scale industrial trial to evaluate the efficacy of a commercial phage product to reduce the prevalence of naturally occurring Salmonella on pork carcasses. The

In a new paper in Nature Microbiology, Charles Dulberger and colleagues show that the mycobacterial nucleoid-associated protein Lsr2 is required for productive mycobacteriophage infection.

A new paper in PNAS by Bin Li and colleagues discusses how viruses require the small polyamine spermidine to replicate normally, in part due to its important role in ribosomal translation. They found genes in many phages and eukaryotic viru

In a new Nature Microbiology paper, Jan Wohlfarth (ETH Zurich) and colleagues show that Listeria and Enterococcus can evade phage predation by transient conversion to a cell wall-deficient L-form state, which is triggered by endolysins disi

A subset of jumbo phages have recently been shown to encode a 'phage nucleus' for sequestering the phage genome away from host nucleolytic attack. Eliza Nieweglowska (University of California, San Francisco) and colleagues published a new p

In a new paper in Cell Reports, Beatriz Beamud (Universidad Complutense de Madrid) and colleagues report on their study of the genetic determinants of host tropism in Klebsiella phages. They isolated 46 phages to challenge 138 representativ

In this new paper in Virus Evolution, Eric Olo Ndela (Université Clermont Auvergne, France) and colleagues report the discovery of sixteen complete microvirus genomes that represent two novel groups of microviruses, tentatively named Reekee

In a new paper in Cell, Brianna Duncan-Lowey (Harvard Medical School) and colleagues determined the cryo-EM structures of the RADAR defense complex, revealing RdrA as a heptameric, two-layered AAA+ ATPase and RdrB as a dodecameric, hollow c

A new paper by Pablo Quirós (Universitat de Barcelona) and colleagues published in The ISME Journal reports the isolation of the first phage infecting some Nitrosomonas species. This polyvalent virulent phage (named ΦNF-1) infected Nitrosom

Soo Khim Chan (University of California San Diego) and colleagues have developed peptides which bind specifically to Pseudomonas phage Good Vibes, which may enable real-time analysis of phage in vivo and monitor the efficacy of phage therap

In this new paper in Frontiers in Microbiology, Qin Qi (Macquarie University, Australia) and colleagues present evidence that temperate and virulent (lytic) bacteriophages (phages) carry integrons. Integrons are mobile genetic elements that

In a new paper in PNAS, Benoit Pons (University of Exeter) and colleagues show that antibiotics that target the protein translation machinery can alter the outcome of bacteria-phage interactions by interfering with the production of phage-e