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Bridget Watson (University of Exeter) and colleagues published a new review in Cell Host & Microbe on coevolution between bacterial CRISPR-Cas systems and their phages. They discuss when and why CRISPR-Cas immunity against phages evolves, a

Malcolm White (University of St Andrews) has received an Advanced Grant from ERC Research to investigate the mechanisms of cyclic nucleotide signalling in bacteria/phage conflict. Postdoc positions will be available from 1st August - please

Locus Biosciences announced the completion of a phase 1b trial of CRISPR-Cas3-enhanced phage targeting E. coli in urinary tract infections. The trial met all the endpoints, and represents the first randomized, placebo-controlled trial using

Yuping Li and Joseph Bondy-Denomy (University of California San Francisco) published a new review in Cell Host & Microbe discussing how anti-CRISPRs affect the ecology and evolution of bacteria and phage.

Repurposing CRISPR systems as antimicrobials is a new strategy being explored, and engineered phages could be a great way to carry them to their targets. Clément Fage (Université Laval, Canada) and colleagues published a new perspective in

The Fineran lab (University of Otago, New Zealand) has openings for PhD students to study phages and CRISPR. Due to border restrictions, applicants must already be in New Zealand.

It was a great week for microbiology; Nobel prizes were awarded for discovering CRISPR-Cas (Emmanuelle Charpentier and Jennifer Doudna) and Hepatitis C (Harvey Alter, Michael Houghton, Charles Rice). The phage field should be especially pro

A new episode of The Economist podcast investigated how viruses shape the world through interviews with Jennifer Doudna on CRISPR and Steffanie Strathdee on phage therapy.

Patrick Pausch (UC Berkeley) and colleagues have published a new paper in Science on a new 'minimal functional' CRISPR-Cas system comprised of a single 70-kDa protein, CasΦ, that they discovered in phages. This system is active in human and

The Bikard Lab (Institut Pasteur, Paris) is hiring a postdoc to study the properties of Cas proteins in bacteria, their interaction with DNA repair pathways, and the mechanism and evolution of CRISPR-Cas systems as phage defense systems

Beatriz Osuna (UCSF) and colleagues published two new papers this week in Cell Host & Microbe: one on how Listeria phages protect their lysogenic genomes by inducing Cas9 degradation and the other detailing how a bifunctional Listeria phage

Beatriz Osuna (UCSF) and colleagues published two new papers this week in Cell Host & Microbe: one on how Listeria phages protect their lysogenic genomes by inducing Cas9 degradation and the other detailing how a bifunctional Listeria phage

Derek Cerchione and colleagues at Editas Medicine in Cambridge have developed a new M13 phage-based directed-evolution strategy and a mutagenesis method called SMOOT to engineer Cas9 nuclease activity. They report the isolation of a Cas9 mu

Derek Cerchione and colleagues at Editas Medicine in Cambridge have developed a new M13 phage-based directed-evolution strategy and a mutagenesis method called SMOOT to engineer Cas9 nuclease activity. They report the isolation of a Cas9 mu

Two groups have published papers showing how jumbo phages can create nucleus-like structures in their hosts to protect phage DNA from CRISPR-Cas systems. Read Senén Mendoza (UCSF) and colleagues' paper on how this works for a Pseudomonas ph

Two groups have published papers showing how jumbo phages can create nucleus-like structures in their hosts to protect phage DNA from CRISPR-Cas systems. Read Senén Mendoza (UCSF) and colleagues' paper on how this works for a Pseudomonas ph

Edze Westra of the University of Exeter has been awarded the 2020 Fleming Prize from the Microbiology Society for his work on CRISPR-CAS molecular mechanisms and evolutionary ecology. This award is the oldest prize awarded by the Microbiolo

Edze Westra of the University of Exeter has been awarded the 2020 Fleming Prize from the Microbiology Society for his work on CRISPR-CAS molecular mechanisms and evolutionary ecology. This award is the oldest prize awarded by the Microbiolo

This project integrates synthetic biology, in vitro and in vivo experiments and mathematical modelling to predict and test the effectiveness and consequences of CRISPR-Cas9-mediated removal of antibiotic resistance from clinical pathogens i

This project integrates synthetic biology, in vitro and in vivo experiments and mathematical modelling to predict and test the effectiveness and consequences of CRISPR-Cas9-mediated removal of antibiotic resistance from clinical pathogens i