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Melissa Cammuso (The Ottawa Hospital) and colleagues have published a preprint in medRxiv on the first use of phage therapy in Canada for life-threatening, MDR Staphylococcus epidermidis periprosthetic joint infection. This ‘n of 1 trial’ d

Julia Kelliher (Los Alamos National Laboratory, New Mexico) and colleagues published the outcomes of a recent microbiome data management workshop focused on standardizing reporting guidelines for environmental and host-associated microbiome

Bhavya Papudeshi (Flinders University) and colleagues published a new preprint on an automated bioinformatics pipeline for phage therapy candidate screening, showing Sphae can rapidly assess phage safety and suitability for therapeutic use

Chao Liu (Chinese Academy of Sciences) and colleagues published a new paper on phage CRISPR-like regulatory RNAs silencing bacterial immunity, showing how phages use crlRNA mimics to hijack host CRISPR-Cas and abortive infection defenses in

It's hard to compare results across human gut virome studies. Michael Shamash (McGill University, Canada) and colleagues show that using 'predicted phage host families' can improve cross-study virome analyses and help detect disease-specifi

François Rousset (Weizmann Institute of Science) and colleagues discovered a new immune signaling molecule: N7-cADPR, which is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential protei

For OMKO1 and LPS-5, two lytic phages used in Felix Biotech’s CF trial recently, Dea M. Müller and colleagues show that determinants of their host range in P. aeruginosa are bacterial receptors, rather than anti-phage defence mechanisms.

Phage protein moonlighting alert! Abdulrazak Alsaleh (Liverpool John Moores University) and colleagues published a new paper on how large serine integrases utilize scavenged phage proteins to control the directionality of integration.

Yuval Mulla (University of Cologne) and colleagues quantified phage amplification rates using a mathematical model called PHORCE, showing that amplification rates of E. coli phages vary widely and that phage-antibiotic interactions depend p

Mark Grevsen Martinet (Jena University Hospital/Friedrich-Schiller University, Germany) and colleagues have published a preprint on how temperate Pf-like phages induced in P. aeruginosa biofilms can modulate phage and antibiotic resistance,

In a new preprint, Aleksander Szymczak (Hirszfeld Institute of Immunology and Experimental Therapy, Poland) and colleagues investigate the triadic dynamics between the gastric microbiome, phageome, and host genotype. They reveal non-univers

In a new preprint, Ritam Das and Janina Rahlff (Friedrich Schiller University Jena, Germany) describe a positive correlation between the number of structural genes and above-average guanine-cytosine (GC) content in phage genomes.

Chutikarn Chitboonthavisuk (University of Wisconsin-Madison) and colleagues published a new preprint on systematic genome-wide discovery of host factors governing phage infectivity. They describe 'PHAGEPACK', a novel assay combining CRISPR

Maik Wolfram-Schauerte (Max Planck Institute for Terrestrial Microbiology) and colleagues published a preprint revealing that T4 phage RNA is NAD-capped, and alters the NAD-cap epitranscriptome of E. coli during infection through a phage-en

The LuxO-OpaR quorum-sensing cascade differentially controls Vibriophage VP882 lysis-lysogeny decision making in liquid and on surfaces, according to a new preprint by Francis Santoriello and Bonnie Bassler at Princeton University.

Kishen Patel and Kimberley Seed (University of California, Berkeley) published a new preprint on how a sporadic phage defense in epidemic Vibrio cholerae (mediated by the toxin-antitoxin system DarTG) is countered by a phage-encoded antitox

Yi Wu and colleagues have discovered synergistic anti-phage activity of bacterial defence systems, shedding light on the compatibility and flexibility of these systems in response to specific environmental pressures.

G. Eric Bastien and colleagues have developed a machine learning model called Virus-Host Interaction Predictor (VHIP) to predict virus-host interactions and reconstruct complex virus-host networks in natural systems.

Larissa Krüger (University of St. Andrews, UK) and colleagues discovered a reversible conjugation mechanism that regulates immune response to phage infection in Bacillus cereus bacteria.

Jason Wilson (University of Sheffield) and colleagues published a new preprint on the molecular mechanism of phage tail contraction, shedding light on the structure of an S-layer-penetrating phage.