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Jonas Fernbach (ETH Zurich) and colleagues used the PhagePromoter algorithm to identify intergenic loci in the S. aureus phage K genome for targeted payload integration, and validated their approach by engineering recombinant phages with bi

Deepto Mozumdar (UCSF) and colleagues show that jumbo phage ΦKZ assembles a lipid vesicle upon infection. This early phage infection (EPI) vesicle contains phage proteins, DNA, host lipids, and membrane proteins. It protects the phage genom

Helena Shomar from Institut Pasteur and colleagues identified over 2000 lanthipeptide biosynthetic gene clusters in Actinobacteria with anti-phage defense properties, which they termed "lanthiphages". These clusters, often found in defense

Sophia Zborowsky (Institut Pasteur) and colleagues demonstrate that alveolar macrophages reduce pulmonary phage density in a murine pneumonia model, limiting phage therapy efficacy against P. aeruginosa.

Chujin Ruan (China Agricultural University) and colleagues have shown that phage predation of E. coli during surface-associated growth increases plasmid transfer. They found that predation slows spatial demixing of two E. coli populations,

This week, Jonathan Moore tells us how (and why) he founded nonprofit GSD Bio to build a lactococcal phage-based vaccine production system as a public good. “Among the many lessons of COVID-19, one of the most profound is this: You don’t ne

Attention phage researchers! You have until Monday June 24th to make your opinions (on phage banks) count! Tobi Nagel (Phages for Global Health) and Francesca Hodges (Innovate UK Business Connect) are working to capture the global phage co

NIAID's June 2024 Division of Microbiology and Infectious Diseases (DMID) Council-approved concepts include new initiatives for 2026 on phage therapy for ESKAPE pathogens.

In a new preprint, Aleksander Szymczak (Hirszfeld Institute of Immunology and Experimental Therapy, Poland) and colleagues investigate the triadic dynamics between the gastric microbiome, phageome, and host genotype. They reveal non-univers

Lizett Ortiz de Ora (UC Irvine) and colleagues have developed "Phollow," a live imaging method to track gut phage transmission in microbial communities and animals, revealing rapid virion uptake and dissemination.

Ryan Cook (Quadram Institute Bioscience, UK) and colleagues have identified many phages that repurpose stop codons to encode amino acids. They re-annotated these sequences with modified versions of Pharokka and Prokka to automatically predi

Mihály Koncz (HUN-REN Biological Research Centre, Szeged, Hungary) demonstrate the utility of pathogen genomic surveillance combined with high-throughput phage typing for enabling phage therapy. Their analysis reveals that a few strain type

In an upcoming course in Lyon, France (Nov 12-13 2024), the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) will explore current clinical experiences, compassionate use protocols, cohort studies, and ongoing clini

Gordon Ramage’s team at the University of Glasgow, UK is hiring 2 PhD students to study the use of phage against clinically important at biofilms.

Vasili Hauryliuk's team at Lund University, Sweden is hiring a postdoc to study molecular mechanisms of antiphage defense.

Oxford Silk Phage Technologies (UK) is hiring a microbiology technician with phage expertise.

In an upcoming course in Lyon, France (Nov 12-13 2024), the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) will explore current clinical experiences, compassionate use protocols, cohort studies, and ongoing clini

In an upcoming course in Lyon, France (Nov 12-13 2024), the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) will explore current clinical experiences, compassionate use protocols, cohort studies, and ongoing clini

In an upcoming course in Lyon, France (Nov 12-13 2024), the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) will explore current clinical experiences, compassionate use protocols, cohort studies, and ongoing clini

The study predicted 76 INPHARED genomes and 712 Unified Human Gut Virome Catalogue vOTUs that repurpose a stop codon to encode an amino acid, and re-annotated them with modified Pharokka-gv and Prokka-gv tools. For sequences predicted to re