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Intralytix announced a multimillion-dollar NIH P01 award for a Pitt-led CAPT-CEP project developing phage therapy for multidrug-resistant Pseudomonas aeruginosa. The collaboration includes Pitt, Walter Reed, USC, Florida International Unive

Parallel sequential fluorescence in situ hybridization (par-seqFISH) profiled the transcriptional activity of individual phage lambda genomes during synchronized infection of E. coli. Cells pursuing lysogeny show consensus activity among al

NIAID awarded three CAPT-CEP centers to build preclinical tools, assays and models for phage therapy against ESKAPE pathogens. The FY 2026 program provides $6 million across three awards, each up to $1.2 million in annual direct costs for u

Meijer, Skiadas, Rainey, Hogeweg and Dutilh tracked viral dynamics in 20 compost-derived microbial communities over one year and observed massive, parallel outbreaks of Theomophage, a previously uncharacterized member of the Schitoviridae t

Metagenomics, metatranscriptomics and metabolic modelling followed a thermophilic CO2-converting (biomethanation) trickle bed reactor over 353 days of stepwise gas-feed perturbations, tracking single nucleotide variant trajectories in both

The study presents DepoCatalog, an experimentally validated collection of 129 recombinantly prepared Klebsiella phage depolymerases across 75 KL-types, and proposes a five-class framework for their diversity. The accompanying DepoCat databa

Science news feature by Richard Stone (Science 392, issue 6800, May 21, 2026, pp. 800-804), whose standfirst states that key human defenses against pathogens were forged billions of years ago in microbial battles with viruses. Science — "Br

Four online information sessions cover the 12-week curriculum, wet-lab practicum and application requirements for PHTRP Journal Club Cohort 004. Sessions were listed in May–June ahead of the June 2026 programme. Phage Hunters Training and R

Researchers profiled 95 Pseudomonas phages against 99 clinical isolates and trained strain-specific models to predict infectivity. In a single held-out strain in vivo, the model-designed cocktail produced a higher median CFU reduction than

PHAGE4DAIR, a Horizon Europe project coordinated by Qeen Biotechnologies (Canada), runs from 1 June 2026 to 31 May 2031 with an EU contribution of €14,869,038.73. It is a multicenter, randomized, double-blind, placebo-controlled, adaptive P

Using the Klebsiella podophages KP32, K11 and KP34, the authors validated the interaction between the primary RBP branching domain and the secondary RBP docking peptide. They used this interaction to engineer a KP32 scaffold that propagated

Biochemistry, cryo-electron microscopy and single-molecule imaging show that Hna, a broadly distributed anti-phage system that triggers abortive infection, is a 3'-5' single-stranded DNA exonuclease forming an auto-inhibited dimer under phy

Phage Consultants (Marcin Łoś, Gdynia, Poland) is developing PhageSense, a platform for rapid, sensitive and repeatable detection of bacteriophage infections in bacterial cultures and industrial fermentation samples that combines fluorescen

A structural and functional study of QatB and QatC, two components of the four-protein QatABCD anti-phage defense system. QatC bound to the ATP analog AMPPNP and the QatB-QatC heterodimer were solved, and structural analysis suggests QatB m

More than two-thirds of Streptococcus thermophilus strains harbor a phage satellite structurally similar to Staphylococcus aureus pathogenicity islands (SaPIs). Virulent phages can trigger induction of these satellites, and their DNA can th

EcoPhage signed an evaluation and pre-commercialization agreement with Dole Fresh Fruit International to apply its technology against bacterial plant diseases in bananas, including Moko disease caused by Ralstonia solanacearum. EcoPhage

A metagenomic study of 450 virus-enriched honey bee gut samples from 63 hives across eight European countries, three seasons and three gut sections catalogues a diverse phageome, including many phages that appear to belong to novel taxa and

Phage Foundry lists PI Vivek Mutalik as A-LIFT’s 2026 Outstanding Mentor of the Year. phagefoundry.org

A Nature Communications Perspective by Aleksandra Petrović-Fabijan and Stephen T. Abedon argues that phage therapy must move beyond anecdote to clinical reproducibility, and identifies three foundational pillars to be addressed through inte

Lytic Selection and Evolution (LySE) uses a modified bacteriophage to evolve long gene clusters. In a proof of concept, the team improved bacterial degradation of a plastic ingredient by more than 50% after five cycles. National University