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Ep 18: Discussion of Phage Therapy for CF Patients - Rebekah Dedrick

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  • Phage prohead proteases activate CBASS antiphage immunity (Science)

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  1. UpdatesJun 6, 2025

    The European Research Executive Agency has announced €7.3 billion in EU funding for research through Horizon Europe 2025 to s

    The European Research Executive Agency has announced €7.3 billion in EU funding for research through Horizon Europe 2025 to support research careers and competitiveness.

    UpdatesFunding opportunity
  2. UpdatesJun 6, 2025

    Atif Khan and Hiren Joshi (Bhabha Atomic Research Centre, India) published a new research paper on selectively enriching and

    Atif Khan and Hiren Joshi (Bhabha Atomic Research Centre, India) published a new research paper on selectively enriching and characterizing stress-tolerant phages for food biocontrol.

    UpdatesResearch paperStress toleranceBiocontrol
  3. UpdatesJun 6, 2025

    Bradley Cook (Cytophage Technologies) and Alexander Hynes (McMaster University) published a new paper on re-evaluating phage

    Bradley Cook (Cytophage Technologies) and Alexander Hynes (McMaster University) published a new paper on re-evaluating phage therapy criteria. They examine three commonly applied criteria for excluding phages from therapy: the lack of virul

    UpdatesPerspectivePhage therapy
  4. UpdatesJun 6, 2025

    Eleanor Rand (Harvard Medical School) and colleagues published a new paper on a targeted phage discovery method called Phage

    Eleanor Rand (Harvard Medical School) and colleagues published a new paper on a targeted phage discovery method called Phage DisCo, a co-culture-based phage screening technique. Using isogenic, fluorescently tagged bacterial strains, they c

    UpdatesResearch paperPhage discoveryMethods
  5. UpdatesMay 30, 2025

    Hi everyone, I'm a researcher based in Argentina working on a phage-based biocontrol project targeting spoilage bacteria in

    Hi everyone, I'm a researcher based in Argentina working on a phage-based biocontrol project targeting spoilage bacteria in industrial fermentations, particularly lactic acid bacteria like Lactobacillus plantarum, L. fermentum, and L. brev

    UpdatesCommunitySeeking help with research methods
  6. UpdatesMay 30, 2025

    Reminder to register for the Phage Protein Meeting, taking place in Ghent, Belgium, on September 10-11, 2025. This interdisci

    Reminder to register for the Phage Protein Meeting, taking place in Ghent, Belgium, on September 10-11, 2025. This interdisciplinary conference will bring together experts working with phage lysins/endolysins, tail fibers, tailspikes, depol

    UpdatesCommunityConferencePhage proteins
  7. UpdatesMay 30, 2025

    Stephen Tang (Columbia University) and colleagues published a new paper on protein-primed homopolymer synthesis, showing a no

    Stephen Tang (Columbia University) and colleagues published a new paper on protein-primed homopolymer synthesis, showing a novel bacterial antiviral defense mechanism involving synthesis of poly-dA DNA triggered by phage infection, driven b

    UpdatesResearch paperPhage defenseMolecular biology
  8. UpdatesMay 30, 2025

    Meaghan Castledine (University of Exeter) and colleagues published a new paper on interactions between phages and macrophages

    Meaghan Castledine (University of Exeter) and colleagues published a new paper on interactions between phages and macrophages, showing macrophages reduced phage efficacy and increased bacterial phage resistance, potentially explaining varia

    UpdatesPhage-immune interactionsMacrophagesPreprint
  9. UpdatesMay 30, 2025

    Liana Merk (Harvard University) and colleagues published a new paper on prevalence of group II introns in phage genomes, show

    Liana Merk (Harvard University) and colleagues published a new paper on prevalence of group II introns in phage genomes, showing group II introns are widely present in phages from diverse phylogenetic backgrounds, contrary to previous assum

    UpdatesPreprintIntronsPhage genome analysis
  10. UpdatesMay 30, 2025

    Nathan Novy (University of Wisconsin-Madison) and colleagues published a new paper on multiobjective learning and design of p

    Nathan Novy (University of Wisconsin-Madison) and colleagues published a new paper on multiobjective learning and design of phage specificity, showing deep learning can enhance T7 phage infectivity and specificity toward diverse bacterial s

    UpdatesMachine learningPhage-host interactionsPreprint
  11. UpdatesMay 30, 2025

    Tianjing She (Nanjing Agricultural University) and colleagues published a new paper on phage-mediated gene transfer in Salmon

    Tianjing She (Nanjing Agricultural University) and colleagues published a new paper on phage-mediated gene transfer in Salmonella, showing horizontal transfer of virulence genes in Salmonella enterica with regulatory feedback from the host.

    UpdatesResearch paperHorizontal gene transfer
  12. UpdatesMay 28, 2025

    Phage DisCo: targeted discovery of bacteriophages by co-culture (mSystems)

    Rand and colleagues present Phage DisCo (phage discovery by co-culture) in mSystems: bacterial strains that are isogenic except for fluorescent tags and one perturbation expected to affect phage infection are co-cultured on the same screeni

    UpdatesPapersPhage Biology
  13. UpdatesMay 28, 2025

    The gut virome in association with the bacteriome in gastrointestinal diseases and beyond (Precision Clinical Medicine)

    Review by Feng et al. in Precision Clinical Medicine on the human gut virome, 90%-95% of which is phages. It examines how the virome develops and how diet, environment, host genetics and immunity shape it, its associations with various dise

    UpdatesPapersReviewMicrobiome
  14. UpdatesMay 23, 2025

    The International Antiviral Society-USA (IAS-USA) is hosting a webinar called 'An Introduction to Bacteriophages: Basic Scien

    The International Antiviral Society-USA (IAS-USA) is hosting a webinar called 'An Introduction to Bacteriophages: Basic Science and Clinical Applications', taking place on June 30, 2025. This webinar consists of 2 lectures by Graham F. Hat

    UpdatesCommunityWebinarPhage biology
  15. UpdatesMay 23, 2025

    Hello phage community! 😃 We’re looking for a T-series E. coli K-12 phage (e.g., T2, T4, T7) engineered to express a red fluo

    Hello phage community! 😃 We’re looking for a T-series E. coli K-12 phage (e.g., T2, T4, T7) engineered to express a red fluorescent protein (e.g., mCherry) fused to a capsid or tail protein — to track intact virions by microscopy. No induc

    UpdatesCommunitySeeking phage for research
  16. UpdatesMay 23, 2025

    Bio Lab in Korea is currently seeking Paenibacillus relictisesami phages and Lysinibacillus macroides phages. If you have acc

    Bio Lab in Korea is currently seeking Paenibacillus relictisesami phages and Lysinibacillus macroides phages. If you have access to these phages and are willing to share them, please get in touch. We would greatly appreciate your support.

    UpdatesCommunitySeeking phage for research
  17. UpdatesMay 23, 2025

    Another successful phage therapy clinical trial! Armata Pharmaceuticals and colleagues has announced positive topline results

    Another successful phage therapy clinical trial! Armata Pharmaceuticals and colleagues has announced positive topline results from its Phase 1b/2a trial of AP-SA02 for S. aureus bacteremia.

    UpdatesBiotech newsClinical trialsPhage therapy
  18. UpdatesMay 23, 2025

    Lukeman Kharrat (San Diego State University) and colleagues published a new paper on phage immunogenicity assessment, showing

    Lukeman Kharrat (San Diego State University) and colleagues published a new paper on phage immunogenicity assessment, showing a novel Bacteriophage Risk Index to predict CpG-mediated immune activation potential of phages and guide selection

    UpdatesPhage immunogenicityPreprint
  19. UpdatesMay 23, 2025

    There’s a lot of improvement we can engineer into phages! Phil Huss (University of Wisconsin-Madison) and colleagues publishe

    There’s a lot of improvement we can engineer into phages! Phil Huss (University of Wisconsin-Madison) and colleagues published a new paper on engineering phages using metagenomic data, showing how deep mining of metagenomic motifs can be us

    UpdatesResearch paperMetagenomicsPhage engineering
  20. UpdatesMay 23, 2025

    David Sünderhauf (University of Exeter) and colleagues published a new paper on CRISPR-Cas in plasmid competition, showing CR

    David Sünderhauf (University of Exeter) and colleagues published a new paper on CRISPR-Cas in plasmid competition, showing CRISPR-Cas benefits plasmids defensively but is limited by competitor toxin-antitoxin systems when horizontally trans

    UpdatesCRISPRPreprintToxin-antitoxins
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