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W. Borges (Yale University) and colleagues published a new abstract on personalized phage therapy for cystic fibrosis, showing an LPS-5 and TIVP-H6 phage cocktail decreased P. aeruginosa biofilm formation and reduced IL-6 secretion for 15 d

Monyque Karoline de Paula Silva (Brazilian Center for Research in Energy and Materials) and colleagues published a new paper on deep learning in phage discovery, showing how AI enhances phage research through improved vMAG reconstruction, h

Robert Brzozowski, Amelia Schmidt (University of Montana) and colleagues published a new paper on prophage-encoded sRNA limiting lytic phage infection, showing a lambdoid prophage in adherent-invasive E. coli encodes an sRNA that downregula

Alexander Perfilyev (University of Copenhagen) and colleagues published a new preprint on discovering lytic phages in bacterial genomes, showing over 100,000 complete lytic phage genomes in bacterial assemblies, challenging assumptions and

Sarah Macdowell (The Ohio State University) and colleagues published a new paper on meropenem interactions with P. aeruginosa phages. They found that phages PEV2 and ΦKMV reduce bacterial burden in vitro and ex vivo, with enhanced efficacy

Alexandre Boulay (Ghent University) and colleagues published a new paper on segmentation of phage endolysin domains, showing SPAED achieves higher accuracy than existing tools by using AlphaFold's predicted aligned error matrix for hierarch

Seyoung Ko (Ulsan National Institute of Science and Technology, Korea) and colleagues published a new paper on deep learning-guided structural analysis of phage KPP105. Structural similarity analysis showed how its receptor binding protein

Benjamin Chan (Yale University) and colleagues published a new paper on outcomes from the first 9 adult CF compassionate use cases treated with personalized inhaled P. aeruginosa phage therapy at Yale. 5-18 days after phage therapy, they sa

Emily Armbruster (University of California San Diego) and colleagues published a new paper on sequential membrane- and protein-bound organelles in phage infection, showing chimalliviruses use two organelles - an early membrane-bound vesicle

Tao Yang (Zhejiang University) and colleagues published a new paper on tumor-homing phage nanofibers for targeted cancer therapy, showing phage-templated platinum nanozymes can enhance photodynamic therapy of breast tumors by alleviating hy

Hollyn Franklin (Virginia Tech) and colleagues published a new paper on a phage-conditional mouse model, showing acriflavine can deplete gut phages without significantly impacting bacteria, allowing study of phage impacts in conventionally

Nadezhda Kolupaeva (State Research Center for Applied Microbiology and Biotechnology, Russia) and colleagues published a new paper on diverse prophage content in A. baumannii and K. pneumoniae bloodstream isolates from patients in the ICU,

Lizett Ortiz de Ora (University of California, Irvine) and colleagues published a new paper on visualizing phage transmission dynamics in zebrafish gut microbiomes, showing antibiotics triggered waves of interbacterial phage transmission an

Hui Yue (Zhejiang University) and colleagues published a new paper on filamentous phages as tumor-targeting immunotherapeutic agents, showing engineered phages can home to tumors and block PD-1/PD-L1 interaction for targeted cancer immunoth

Amalie Høgh Eichler (University of Copenhagen) and colleagues published a new paper on PQS stability in phage lysates, showing PQS is highly stable in phage lysates for up to a year and can induce quorum sensing responses when carried over,

Giuseppina Mariano, Justin Deme (University of Glasgow & National Cancer Institute) and colleagues published a new paper on structural and mechanistic insights into Zorya phage defense systems, showing ZorAB forms an ion-driven motor comple

Jason Wilson (University of Sheffield) and colleagues published a new paper on structural analysis of a phage that penetrates bacterial S-layers, showing the phage has an unusually long tail that contracts less than other phages, likely ena

Isabella Romano (University of New Mexico) and colleagues published a new paper on RNA phage-derived vaccines against heroin and fentanyl, showing the vaccines elicit high-titer antibodies and protect against opioid-induced effects in mice

Li Yuping (University of California, San Francisco) and colleagues published a new paper on a bacterial immune system targeting jumbo phages, showing it disrupts an early phage infection compartment to block replication.

Brittany Supina (University of Alberta) and colleagues published a new paper on isolation and characterization of a novel Burkholderia jumbo phage, showing it uses flagella as a receptor, controls rice seedling rot, and steers B. glumae tow